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Protein

Gamma-aminobutyric acid receptor subunit rho-3

Gene

GABRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: UniProtKB
  • gamma-aminobutyric acid signaling pathway Source: UniProtKB

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-977442 GABA A (rho) receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-3
Alternative name(s):
GABA(A) receptor subunit rho-3
GABA(C) receptor
Gene namesi
Name:GABRR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000183185.9
HGNCiHGNC:17969 GABRR3
neXtProtiNX_A8MPY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 266ExtracellularSequence analysisAdd BLAST243
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 299CytoplasmicSequence analysisAdd BLAST12
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 331ExtracellularSequence analysisAdd BLAST11
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Topological domaini353 – 446CytoplasmicSequence analysisAdd BLAST94
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi200959
OpenTargetsiENSG00000183185
PharmGKBiPA134952133

Chemistry databases

ChEMBLiCHEMBL2109242
DrugBankiDB00546 Adinazolam
DB01558 Bromazepam
DB01594 Cinolazepam
DB01559 Clotiazepam
DB00829 Diazepam
DB01215 Estazolam
DB01567 Fludiazepam
DB00690 Flurazepam
DB00801 Halazepam
DB00683 Midazolam
DB01595 Nitrazepam
DB00842 Oxazepam
DB01588 Prazepam
DB01589 Quazepam
DB00231 Temazepam
DB00897 Triazolam

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000033218924 – 467Gamma-aminobutyric acid receptor subunit rho-3Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi184 ↔ 198By similarity
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA8MPY1
PRIDEiA8MPY1

PTM databases

iPTMnetiA8MPY1
PhosphoSitePlusiA8MPY1

Expressioni

Gene expression databases

BgeeiENSG00000183185
CleanExiHS_GABRR3
GenevisibleiA8MPY1 HS

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000471569

Chemistry databases

BindingDBiA8MPY1

Structurei

3D structure databases

ProteinModelPortaliA8MPY1
SMRiA8MPY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni347 – 448Interaction with SQSTM1By similarityAdd BLAST102

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOVERGENiHBG051707
InParanoidiA8MPY1
KOiK05190
OMAiFTMTFYL
OrthoDBiEOG091G0805
PhylomeDBiA8MPY1

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MPY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK
60 70 80 90 100
DDSTKARPQK YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET
110 120 130 140 150
NMDFTMTFYL RHYWKDERLS FPSTANKSMT FDHRLTRKIW VPDIFFVHSK
160 170 180 190 200
RSFIHDTTME NIMLRVHPDG NVLLSLRITV SAMCFMDFSR FPLDTQNCSL
210 220 230 240 250
ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS ASSGLAFYSS
260 270 280 290 300
TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV
310 320 330 340 350
SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA
360 370 380 390 400
VNYLTTVEER KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS
410 420 430 440 450
LNSEDFMRRK SICSPSTDSS RIKRRKSLGG HVGRIILENN HVIDTYSRIL
460
FPIVYILFNL FYWGVYV
Length:467
Mass (Da):54,272
Last modified:April 29, 2008 - v2
Checksum:iA374DCA1CF6079C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026100 Genomic DNA No translation available.
Y18994 Genomic DNA Translation: CAB60835.1
CCDSiCCDS54617.1
RefSeqiNP_001099050.1, NM_001105580.2
UniGeneiHs.534578

Genome annotation databases

EnsembliENST00000472788; ENSP00000420790; ENSG00000183185
ENST00000621172; ENSP00000481321; ENSG00000183185
GeneIDi200959
KEGGihsa:200959
UCSCiuc021xbo.2 human

Similar proteinsi

Entry informationi

Entry nameiGBRR3_HUMAN
AccessioniPrimary (citable) accession number: A8MPY1
Secondary accession number(s): Q9UIV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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