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A8MPY1

- GBRR3_HUMAN

UniProt

A8MPY1 - GBRR3_HUMAN

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Protein

Gamma-aminobutyric acid receptor subunit rho-3

Gene

GABRR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: UniProtKB

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: UniProtKB
  2. ion transmembrane transport Source: Reactome
  3. synaptic transmission Source: UniProtKB
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_25168. GABA A (rho) receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-3
Alternative name(s):
GABA(A) receptor subunit rho-3
GABA(C) receptor
Gene namesi
Name:GABRR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17969. GABRR3.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 467444Gamma-aminobutyric acid receptor subunit rho-3PRO_0000332189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi184 ↔ 198By similarity
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA8MPY1.
PRIDEiA8MPY1.

PTM databases

PhosphoSiteiA8MPY1.

Expressioni

Gene expression databases

CleanExiHS_GABRR3.
GenevestigatoriA8MPY1.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ By similarity.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000328115.

Structurei

3D structure databases

ProteinModelPortaliA8MPY1.
SMRiA8MPY1. Positions 66-467.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 266243ExtracellularSequence AnalysisAdd
BLAST
Topological domaini288 – 29912CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini321 – 33111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini353 – 44694CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni347 – 448102Interaction with SQSTM1By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOVERGENiHBG051707.
InParanoidiA8MPY1.
KOiK05190.
PhylomeDBiA8MPY1.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MPY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK
60 70 80 90 100
DDSTKARPQK YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET
110 120 130 140 150
NMDFTMTFYL RHYWKDERLS FPSTANKSMT FDHRLTRKIW VPDIFFVHSK
160 170 180 190 200
RSFIHDTTME NIMLRVHPDG NVLLSLRITV SAMCFMDFSR FPLDTQNCSL
210 220 230 240 250
ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS ASSGLAFYSS
260 270 280 290 300
TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV
310 320 330 340 350
SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA
360 370 380 390 400
VNYLTTVEER KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS
410 420 430 440 450
LNSEDFMRRK SICSPSTDSS RIKRRKSLGG HVGRIILENN HVIDTYSRIL
460
FPIVYILFNL FYWGVYV
Length:467
Mass (Da):54,272
Last modified:April 29, 2008 - v2
Checksum:iA374DCA1CF6079C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026100 Genomic DNA. No translation available.
Y18994 Genomic DNA. Translation: CAB60835.1.
CCDSiCCDS54617.1.
RefSeqiNP_001099050.1. NM_001105580.2.
UniGeneiHs.534578.

Genome annotation databases

EnsembliENST00000472788; ENSP00000420790; ENSG00000183185.
ENST00000621172; ENSP00000481321; ENSG00000183185.
GeneIDi200959.
KEGGihsa:200959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026100 Genomic DNA. No translation available.
Y18994 Genomic DNA. Translation: CAB60835.1 .
CCDSi CCDS54617.1.
RefSeqi NP_001099050.1. NM_001105580.2.
UniGenei Hs.534578.

3D structure databases

ProteinModelPortali A8MPY1.
SMRi A8MPY1. Positions 66-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328115.

Chemistry

BindingDBi A8MPY1.
ChEMBLi CHEMBL2109242.
DrugBanki DB00546. Adinazolam.
DB01558. Bromazepam.
DB01594. Cinolazepam.
DB01559. Clotiazepam.
DB00829. Diazepam.
DB01215. Estazolam.
DB01567. Fludiazepam.
DB00690. Flurazepam.
DB00801. Halazepam.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00842. Oxazepam.
DB01588. Prazepam.
DB01589. Quazepam.
DB00231. Temazepam.
DB00897. Triazolam.
GuidetoPHARMACOLOGYi 422.

PTM databases

PhosphoSitei A8MPY1.

Proteomic databases

PaxDbi A8MPY1.
PRIDEi A8MPY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000472788 ; ENSP00000420790 ; ENSG00000183185 .
ENST00000621172 ; ENSP00000481321 ; ENSG00000183185 .
GeneIDi 200959.
KEGGi hsa:200959.

Organism-specific databases

CTDi 200959.
GeneCardsi GC03M097705.
HGNCi HGNC:17969. GABRR3.
neXtProti NX_A8MPY1.
PharmGKBi PA134952133.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77438.
GeneTreei ENSGT00760000118821.
HOVERGENi HBG051707.
InParanoidi A8MPY1.
KOi K05190.
PhylomeDBi A8MPY1.

Enzyme and pathway databases

Reactomei REACT_25168. GABA A (rho) receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Miscellaneous databases

GeneWikii GABRR3.
GenomeRNAii 200959.
NextBioi 90035.
PROi A8MPY1.

Gene expression databases

CleanExi HS_GABRR3.
Genevestigatori A8MPY1.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3."
    Bailey M.E.S., Albrecht B.E., Johnson K.J., Darlison M.G.
    Biochim. Biophys. Acta 1447:307-312(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 369-467.

Entry informationi

Entry nameiGBRR3_HUMAN
AccessioniPrimary (citable) accession number: A8MPY1
Secondary accession number(s): Q9UIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3