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Protein

Gamma-aminobutyric acid receptor subunit rho-3

Gene

GABRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: UniProtKB

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: UniProtKB
  2. ion transmembrane transport Source: Reactome
  3. synaptic transmission Source: UniProtKB
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_25168. GABA A (rho) receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-3
Alternative name(s):
GABA(A) receptor subunit rho-3
GABA(C) receptor
Gene namesi
Name:GABRR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17969. GABRR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 266243ExtracellularSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Topological domaini288 – 29912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST
Topological domaini321 – 33111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence AnalysisAdd
BLAST
Topological domaini353 – 44694CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952133.

Chemistry

DrugBankiDB00546. Adinazolam.
DB01558. Bromazepam.
DB01594. Cinolazepam.
DB01559. Clotiazepam.
DB00829. Diazepam.
DB01215. Estazolam.
DB01567. Fludiazepam.
DB00690. Flurazepam.
DB00801. Halazepam.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00842. Oxazepam.
DB01588. Prazepam.
DB01589. Quazepam.
DB00231. Temazepam.
DB00897. Triazolam.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 467444Gamma-aminobutyric acid receptor subunit rho-3PRO_0000332189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi184 ↔ 198By similarity
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA8MPY1.
PRIDEiA8MPY1.

PTM databases

PhosphoSiteiA8MPY1.

Expressioni

Gene expression databases

CleanExiHS_GABRR3.
GenevestigatoriA8MPY1.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000328115.

Structurei

3D structure databases

ProteinModelPortaliA8MPY1.
SMRiA8MPY1. Positions 71-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni347 – 448102Interaction with SQSTM1By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOVERGENiHBG051707.
InParanoidiA8MPY1.
KOiK05190.
PhylomeDBiA8MPY1.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MPY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK
60 70 80 90 100
DDSTKARPQK YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET
110 120 130 140 150
NMDFTMTFYL RHYWKDERLS FPSTANKSMT FDHRLTRKIW VPDIFFVHSK
160 170 180 190 200
RSFIHDTTME NIMLRVHPDG NVLLSLRITV SAMCFMDFSR FPLDTQNCSL
210 220 230 240 250
ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS ASSGLAFYSS
260 270 280 290 300
TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV
310 320 330 340 350
SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA
360 370 380 390 400
VNYLTTVEER KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS
410 420 430 440 450
LNSEDFMRRK SICSPSTDSS RIKRRKSLGG HVGRIILENN HVIDTYSRIL
460
FPIVYILFNL FYWGVYV
Length:467
Mass (Da):54,272
Last modified:April 29, 2008 - v2
Checksum:iA374DCA1CF6079C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026100 Genomic DNA. No translation available.
Y18994 Genomic DNA. Translation: CAB60835.1.
CCDSiCCDS54617.1.
RefSeqiNP_001099050.1. NM_001105580.2.
UniGeneiHs.534578.

Genome annotation databases

EnsembliENST00000472788; ENSP00000420790; ENSG00000183185.
ENST00000621172; ENSP00000481321; ENSG00000183185.
GeneIDi200959.
KEGGihsa:200959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026100 Genomic DNA. No translation available.
Y18994 Genomic DNA. Translation: CAB60835.1.
CCDSiCCDS54617.1.
RefSeqiNP_001099050.1. NM_001105580.2.
UniGeneiHs.534578.

3D structure databases

ProteinModelPortaliA8MPY1.
SMRiA8MPY1. Positions 71-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328115.

Chemistry

BindingDBiA8MPY1.
ChEMBLiCHEMBL2109242.
DrugBankiDB00546. Adinazolam.
DB01558. Bromazepam.
DB01594. Cinolazepam.
DB01559. Clotiazepam.
DB00829. Diazepam.
DB01215. Estazolam.
DB01567. Fludiazepam.
DB00690. Flurazepam.
DB00801. Halazepam.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00842. Oxazepam.
DB01588. Prazepam.
DB01589. Quazepam.
DB00231. Temazepam.
DB00897. Triazolam.
GuidetoPHARMACOLOGYi422.

PTM databases

PhosphoSiteiA8MPY1.

Proteomic databases

PaxDbiA8MPY1.
PRIDEiA8MPY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000472788; ENSP00000420790; ENSG00000183185.
ENST00000621172; ENSP00000481321; ENSG00000183185.
GeneIDi200959.
KEGGihsa:200959.

Organism-specific databases

CTDi200959.
GeneCardsiGC03M097705.
HGNCiHGNC:17969. GABRR3.
neXtProtiNX_A8MPY1.
PharmGKBiPA134952133.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOVERGENiHBG051707.
InParanoidiA8MPY1.
KOiK05190.
PhylomeDBiA8MPY1.

Enzyme and pathway databases

ReactomeiREACT_25168. GABA A (rho) receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Miscellaneous databases

GeneWikiiGABRR3.
GenomeRNAii200959.
NextBioi90035.
PROiA8MPY1.

Gene expression databases

CleanExiHS_GABRR3.
GenevestigatoriA8MPY1.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3."
    Bailey M.E.S., Albrecht B.E., Johnson K.J., Darlison M.G.
    Biochim. Biophys. Acta 1447:307-312(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 369-467.

Entry informationi

Entry nameiGBRR3_HUMAN
AccessioniPrimary (citable) accession number: A8MPY1
Secondary accession number(s): Q9UIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 29, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.