A8MPS7 (YDJC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0249 protein ydjC homolog

Gene names

Name:

YDJC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the UPF0249 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A8MPS7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A8MPS7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     143-149: VCQVFAE → GQTPSWA
     150-323: Missing.

Isoform 3 (identifier: A8MPS7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: EELEAQLSCFRELLGRAPTHADGHQH → SRSYRRMLARTPRAPPGGCGRSSRPN
     137-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	UPF0249 protein ydjC homolog		PRO_0000328774
Natural variations
	Alternative sequence	111 – 136	26	EELEA…DGHQH → SRSYRRMLARTPRAPPGGCG RSSRPN in isoform 3.		VSP_032784
	Alternative sequence	137 – 323	187	Missing in isoform 3.		VSP_032785
	Alternative sequence	143 – 149	7	VCQVFAE → GQTPSWA in isoform 2.		VSP_032786
	Alternative sequence	150 – 323	174	Missing in isoform 2.		VSP_032787
	Natural variant	263	1	A → T. Corresponds to variant rs2298428 [ dbSNP | Ensembl ].		VAR_042519

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: CAD754CCCC4D99A4	FASTA	323	34,466
	10 20 30 40 50 60 MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT 70 80 90 100 110 120 GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR EELEAQLSCF 130 140 150 160 170 180 RELLGRAPTH ADGHQHVHVL PGVCQVFAEA LQAYGVRFTR LPLERGVGGC TWLEAPARAF 190 200 210 220 230 240 ACAVERDARA AVGPFSRHGL RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA 250 260 270 280 290 300 ELMAHPGYPS VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD 310 320 SKRPGEEVPC EPTLEPFLEP SLL
	Isoform 2 [UniParc]. Checksum: B3CB5BE8D53252EB	FASTA	149	15,835
	10 20 30 40 50 60 MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT 70 80 90 100 110 120 GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR EELEAQLSCF 130 140 RELLGRAPTH ADGHQHVHVL PGGQTPSWA
	Isoform 3 [UniParc]. Checksum: F6B39A635F5B078C	FASTA	136	14,446
	10 20 30 40 50 60 MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT 70 80 90 100 110 120 GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR SRSYRRMLAR 130 TPRAPPGGCG RSSRPN

References

[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000553 Genomic DNA. No translation available. CH471095 Genomic DNA. Translation: EAW59461.1. CH471095 Genomic DNA. Translation: EAW59463.1. BC096754 mRNA. No translation available. BC110075 mRNA. Translation: AAI10076.1. BC133043 mRNA. Translation: AAI33044.1. BC133047 mRNA. Translation: AAI33048.1.
IPI	IPI00216565. IPI00604761. IPI00871920.
RefSeq	NP_001017964.1. NM_001017964.1.
UniGene	Hs.355952.
3D structure databases
ProteinModelPortal	A8MPS7.
SMR	A8MPS7. Positions 6-300.
ModBase	Search...
Protein-protein interaction databases
STRING	A8MPS7.
Proteomic databases
PRIDE	A8MPS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292778; ENSP00000292778; ENSG00000161179.
GeneID	150223.
KEGG	hsa:150223.
UCSC	uc002zvb.1. human. uc002zvd.1. human.
Organism-specific databases
CTD	150223.
GeneCards	GC22M021982.
HGNC	HGNC:27158. YDJC.
neXtProt	NX_A8MPS7.
PharmGKB	PA162409362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15567.
GeneTree	ENSGT00390000002575.
HOGENOM	HBG716502.
HOVERGEN	HBG054530.
InParanoid	A8MPS7.
OMA	FFHGKMG.
PhylomeDB	A8MPS7.
Gene expression databases
Bgee	A8MPS7.
CleanEx	HS_YDJC.
Genevestigator	A8MPS7.
Family and domain databases
InterPro	IPR002509. Polysac_deacetylase. IPR006879. Uncharacterised_UPF0249/HpnK. [Graphical view]
Gene3D	G3DSA:3.20.20.370. Polysac_deacetylase. 1 hit.
Pfam	PF04794. YdjC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	86371.

Entry information

Entry name

YDJC_HUMAN

Accession

Primary (citable) accession number: A8MPS7
Secondary accession number(s): Q2YDT4, Q4V9R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.