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Protein

Carbohydrate deacetylase

Gene

YDJC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131Proton acceptorBy similarity
Metal bindingi14 – 141MagnesiumBy similarity
Metal bindingi134 – 1341Magnesium; via pros nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate deacetylaseBy similarity (EC:3.5.1.-By similarity)
Gene namesi
Name:YDJC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:27158. YDJC.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409362.

Polymorphism and mutation databases

BioMutaiYDJC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Carbohydrate deacetylasePRO_0000328774Add
BLAST

Proteomic databases

EPDiA8MPS7.
MaxQBiA8MPS7.
PaxDbiA8MPS7.
PRIDEiA8MPS7.

PTM databases

PhosphoSiteiA8MPS7.

Expressioni

Gene expression databases

BgeeiA8MPS7.
CleanExiHS_YDJC.
ExpressionAtlasiA8MPS7. baseline and differential.
GenevisibleiA8MPS7. HS.

Interactioni

Protein-protein interaction databases

BioGridi127272. 4 interactions.
STRINGi9606.ENSP00000292778.

Structurei

3D structure databases

ProteinModelPortaliA8MPS7.
SMRiA8MPS7. Positions 7-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YdjC deacetylase family.Curated

Phylogenomic databases

eggNOGiENOG410II1X. Eukaryota.
COG3394. LUCA.
GeneTreeiENSGT00390000002575.
HOGENOMiHOG000225034.
HOVERGENiHBG054530.
InParanoidiA8MPS7.
OMAiHGKMGFR.
OrthoDBiEOG7HB59J.
PhylomeDBiA8MPS7.
TreeFamiTF329340.

Family and domain databases

Gene3Di3.20.20.370. 1 hit.
InterProiIPR006879. ChbG-like.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF04794. YdjC. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MPS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA
60 70 80 90 100
ELARRHSIPT GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA
110 120 130 140 150
AGDVDLPQVR EELEAQLSCF RELLGRAPTH ADGHQHVHVL PGVCQVFAEA
160 170 180 190 200
LQAYGVRFTR LPLERGVGGC TWLEAPARAF ACAVERDARA AVGPFSRHGL
210 220 230 240 250
RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA ELMAHPGYPS
260 270 280 290 300
VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD
310 320
SKRPGEEVPC EPTLEPFLEP SLL
Length:323
Mass (Da):34,466
Last modified:December 4, 2007 - v1
Checksum:iCAD754CCCC4D99A4
GO
Isoform 2 (identifier: A8MPS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-149: VCQVFAE → GQTPSWA
     150-323: Missing.

Show »
Length:149
Mass (Da):15,835
Checksum:iB3CB5BE8D53252EB
GO
Isoform 3 (identifier: A8MPS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: EELEAQLSCFRELLGRAPTHADGHQH → SRSYRRMLARTPRAPPGGCGRSSRPN
     137-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:136
Mass (Da):14,446
Checksum:iF6B39A635F5B078C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631A → T.
Corresponds to variant rs2298428 [ dbSNP | Ensembl ].
VAR_042519

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei111 – 13626EELEA…DGHQH → SRSYRRMLARTPRAPPGGCG RSSRPN in isoform 3. 1 PublicationVSP_032784Add
BLAST
Alternative sequencei137 – 323187Missing in isoform 3. 1 PublicationVSP_032785Add
BLAST
Alternative sequencei143 – 1497VCQVFAE → GQTPSWA in isoform 2. 1 PublicationVSP_032786
Alternative sequencei150 – 323174Missing in isoform 2. 1 PublicationVSP_032787Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000553 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59461.1.
CH471095 Genomic DNA. Translation: EAW59463.1.
BC096754 mRNA. No translation available.
BC110075 mRNA. Translation: AAI10076.1.
BC133043 mRNA. Translation: AAI33044.1.
BC133047 mRNA. Translation: AAI33048.1.
CCDSiCCDS33613.1. [A8MPS7-1]
RefSeqiNP_001017964.1. NM_001017964.1. [A8MPS7-1]
XP_011528208.1. XM_011529906.1. [A8MPS7-2]
UniGeneiHs.355952.

Genome annotation databases

EnsembliENST00000292778; ENSP00000292778; ENSG00000161179. [A8MPS7-1]
ENST00000398873; ENSP00000381847; ENSG00000161179. [A8MPS7-2]
ENST00000415762; ENSP00000402481; ENSG00000161179. [A8MPS7-3]
GeneIDi150223.
KEGGihsa:150223.
UCSCiuc002zvb.4. human. [A8MPS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000553 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59461.1.
CH471095 Genomic DNA. Translation: EAW59463.1.
BC096754 mRNA. No translation available.
BC110075 mRNA. Translation: AAI10076.1.
BC133043 mRNA. Translation: AAI33044.1.
BC133047 mRNA. Translation: AAI33048.1.
CCDSiCCDS33613.1. [A8MPS7-1]
RefSeqiNP_001017964.1. NM_001017964.1. [A8MPS7-1]
XP_011528208.1. XM_011529906.1. [A8MPS7-2]
UniGeneiHs.355952.

3D structure databases

ProteinModelPortaliA8MPS7.
SMRiA8MPS7. Positions 7-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127272. 4 interactions.
STRINGi9606.ENSP00000292778.

PTM databases

PhosphoSiteiA8MPS7.

Polymorphism and mutation databases

BioMutaiYDJC.

Proteomic databases

EPDiA8MPS7.
MaxQBiA8MPS7.
PaxDbiA8MPS7.
PRIDEiA8MPS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292778; ENSP00000292778; ENSG00000161179. [A8MPS7-1]
ENST00000398873; ENSP00000381847; ENSG00000161179. [A8MPS7-2]
ENST00000415762; ENSP00000402481; ENSG00000161179. [A8MPS7-3]
GeneIDi150223.
KEGGihsa:150223.
UCSCiuc002zvb.4. human. [A8MPS7-1]

Organism-specific databases

CTDi150223.
GeneCardsiYDJC.
HGNCiHGNC:27158. YDJC.
neXtProtiNX_A8MPS7.
PharmGKBiPA162409362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1X. Eukaryota.
COG3394. LUCA.
GeneTreeiENSGT00390000002575.
HOGENOMiHOG000225034.
HOVERGENiHBG054530.
InParanoidiA8MPS7.
OMAiHGKMGFR.
OrthoDBiEOG7HB59J.
PhylomeDBiA8MPS7.
TreeFamiTF329340.

Miscellaneous databases

ChiTaRSiYDJC. human.
GenomeRNAii150223.
NextBioi86371.
PROiA8MPS7.

Gene expression databases

BgeeiA8MPS7.
CleanExiHS_YDJC.
ExpressionAtlasiA8MPS7. baseline and differential.
GenevisibleiA8MPS7. HS.

Family and domain databases

Gene3Di3.20.20.370. 1 hit.
InterProiIPR006879. ChbG-like.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
[Graphical view]
PfamiPF04794. YdjC. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYDJC_HUMAN
AccessioniPrimary (citable) accession number: A8MPS7
Secondary accession number(s): Q2YDT4, Q4V9R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 4, 2007
Last modified: March 16, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.