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A8MLI9

- PUR9_ALKOO

UniProt

A8MLI9 - PUR9_ALKOO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Clos_0541
Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciAORE350688:GHBG-559-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Clos_0541
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_0541.

Structurei

3D structure databases

ProteinModelPortaliA8MLI9.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MLI9-1 [UniParc]FASTAAdd to Basket

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MVKRALLSVS DKEGIVQLAQ NLSSFNIEIL STGGTAKLLR ESGIDVRDVS    50
EVTGFPECLD GRVKTLHPAV HGGILAIRDN ANHMDTLKEL EITPIDLVVI 100
NLYPFKETIL KSDVTLAEAI ENIDIGGPTM LRAAAKNHRD VTVIIDPKDY 150
HRVLEEIKEN GDTKLDTRYQ LALKVFQHTA QYDALIADYL GKQISEEKIG 200
ANTITLTYEK VQDLRYGENP HQKAGFYKEI GANKGTLVDG VQLHGKELSF 250
NNINDANGAL ELLKEFQEPT VVAVKHTNPC GVASGTNIEE AWHKAYESDP 300
LSIFGGIVAA NRAVTKTMAA AMKEIFLEVI IAPNFTEEAL EVFKEKKNLR 350
LIKIEDICNG NHHSYQIKKV QGGILLQEDD HILFEQLDVV TEKEPTEEEK 400
EDLAFAFKIV KHVKSNGIVF VKNKQTLAIG PGQTSRIWAL ENAVKNTTHS 450
LKGSVLASDA FFPFRDCVDT AFGAGVKAII QPGGSINDGV SIKACNEHGI 500
SMVFTGFRHF KH 512
Length:512
Mass (Da):56,446
Last modified:December 4, 2007 - v1
Checksum:i6287884482E96EBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW18103.1.
RefSeqiYP_001512099.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW18103; ABW18103; Clos_0541.
GeneIDi5678038.
KEGGiaoe:Clos_0541.
PATRICi20866183. VBIAlkOre124042_0560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW18103.1 .
RefSeqi YP_001512099.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MLI9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 350688.Clos_0541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW18103 ; ABW18103 ; Clos_0541 .
GeneIDi 5678038.
KEGGi aoe:Clos_0541.
PATRICi 20866183. VBIAlkOre124042_0560.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci AORE350688:GHBG-559-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiPUR9_ALKOO
AccessioniPrimary (citable) accession number: A8MLI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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