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A8MLI9

- PUR9_ALKOO

UniProt

A8MLI9 - PUR9_ALKOO

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciAORE350688:GHBG-559-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Clos_0541
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Bifunctional purine biosynthesis protein PurHPRO_1000057893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_0541.

Structurei

3D structure databases

ProteinModelPortaliA8MLI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MLI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKRALLSVS DKEGIVQLAQ NLSSFNIEIL STGGTAKLLR ESGIDVRDVS
60 70 80 90 100
EVTGFPECLD GRVKTLHPAV HGGILAIRDN ANHMDTLKEL EITPIDLVVI
110 120 130 140 150
NLYPFKETIL KSDVTLAEAI ENIDIGGPTM LRAAAKNHRD VTVIIDPKDY
160 170 180 190 200
HRVLEEIKEN GDTKLDTRYQ LALKVFQHTA QYDALIADYL GKQISEEKIG
210 220 230 240 250
ANTITLTYEK VQDLRYGENP HQKAGFYKEI GANKGTLVDG VQLHGKELSF
260 270 280 290 300
NNINDANGAL ELLKEFQEPT VVAVKHTNPC GVASGTNIEE AWHKAYESDP
310 320 330 340 350
LSIFGGIVAA NRAVTKTMAA AMKEIFLEVI IAPNFTEEAL EVFKEKKNLR
360 370 380 390 400
LIKIEDICNG NHHSYQIKKV QGGILLQEDD HILFEQLDVV TEKEPTEEEK
410 420 430 440 450
EDLAFAFKIV KHVKSNGIVF VKNKQTLAIG PGQTSRIWAL ENAVKNTTHS
460 470 480 490 500
LKGSVLASDA FFPFRDCVDT AFGAGVKAII QPGGSINDGV SIKACNEHGI
510
SMVFTGFRHF KH
Length:512
Mass (Da):56,446
Last modified:December 4, 2007 - v1
Checksum:i6287884482E96EBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW18103.1.
RefSeqiYP_001512099.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW18103; ABW18103; Clos_0541.
GeneIDi5678038.
KEGGiaoe:Clos_0541.
PATRICi20866183. VBIAlkOre124042_0560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW18103.1 .
RefSeqi YP_001512099.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MLI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_0541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW18103 ; ABW18103 ; Clos_0541 .
GeneIDi 5678038.
KEGGi aoe:Clos_0541.
PATRICi 20866183. VBIAlkOre124042_0560.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci AORE350688:GHBG-559-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiPUR9_ALKOO
AccessioniPrimary (citable) accession number: A8MLI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3