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A8MKD9 (SYR_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Clos_2740
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000198869

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A8MKD9 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 49E70A6DFD7C614E

FASTA58766,303
        10         20         30         40         50         60 
MELLIKQISA FVEDVFEQKG YDKKYGMVTV SDRPDLCQFQ CNGALPAAKE YKKAPIQIAN 

        70         80         90        100        110        120 
DLLPALKNVE IFEEITIAGP GFININVKDS FLAAYVNEMY GSEKLGLEEP AEPQTIIIDY 

       130        140        150        160        170        180 
GGANVAKPLH VGHLRAAIIG ESLKRISRFV GHKVIGDVHL GDWGLQMGMV ISELRRRSPH 

       190        200        210        220        230        240 
LPYFDESYEG EYPAEAPFTI DELEDIYPAA SKLAKSDAAA MEEAQQATAE LQKGRRGYMA 

       250        260        270        280        290        300 
LWQHILNVSV ADLKKGYGNL NVDFDLWNGE SDCQKYIDVM VDYLKKNNYT SFSDGLLIVD 

       310        320        330        340        350        360 
VAKETDNHVI PPFIVLKTDG SSLYSTTDLA TIWERVQDYD PDQIIYVVDK RQELHFEQVF 

       370        380        390        400        410        420 
RCAKKTKIAG EDLTLKFLGF GTMNGKDGKP FKTREGGVMR LQDLIQIIKD AVYNKLQENE 

       430        440        450        460        470        480 
AIDPSEVDEI SRKVGLAALK YGDLSNQITK DYVFDIDRFA SFEGNTGPYI LYTIVRIKSI 

       490        500        510        520        530        540 
LRRIAAEGFQ ASDKIGVPHS DVERSLLLKL SRFNETVEFS FVNHSPNRIC DYIYDLANTF 

       550        560        570        580 
NKFYHDTKII SETEFEKKSS WINLITLTMN VLETCLELLG IEAPEKM 

« Hide

References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000853 Genomic DNA. Translation: ABW20271.1.
RefSeqYP_001514267.1. NC_009922.1.

3D structure databases

ProteinModelPortalA8MKD9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING350688.Clos_2740.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW20271; ABW20271; Clos_2740.
GeneID5678008.
KEGGaoe:Clos_2740.
PATRIC20870966. VBIAlkOre124042_2860.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OMAKLEINIG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycAORE350688:GHBG-2853-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_ALKOO
AccessionPrimary (citable) accession number: A8MKD9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries