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A8MJY8

- A8MJY8_ALKOO

UniProt

A8MJY8 - A8MJY8_ALKOO

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Protein

Thymidine kinase

Gene

tdk

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi152 – 1521ZincUniRule annotation
Metal bindingi187 – 1871ZincUniRule annotation
Metal bindingi190 – 1901ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258ATPUniRule annotation
Nucleotide bindingi92 – 954ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAORE350688:GHBG-2702-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Clos_2589Imported
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))Imported
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi350688.Clos_2589.

Structurei

3D structure databases

ProteinModelPortaliA8MJY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MJY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDFIEYSKG GSIEVIVGPM YAGKSEELMR RVNRCRIANL KVLSFKPAID
60 70 80 90 100
NRYSTNHITS HSGKQMECIP VSSPEEILGH LENKDFDVLA IDEVQFLGED
110 120 130 140 150
IVKICKDAAD MGKRVICSGL DMDFRGEPFQ VVPNLMAIAE YVTKLTAVCM
160 170 180 190
KCKVPATRTQ RIVNGKPAKY DDPIIMVGAK ESYEARCRAC HEVIK
Length:195
Mass (Da):21,790
Last modified:December 4, 2007 - v1
Checksum:iD607A4475268565F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW20120.1.
RefSeqiYP_001514116.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW20120; ABW20120; Clos_2589.
GeneIDi5677263.
KEGGiaoe:Clos_2589.
PATRICi20870658. VBIAlkOre124042_2706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW20120.1 .
RefSeqi YP_001514116.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MJY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_2589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW20120 ; ABW20120 ; Clos_2589 .
GeneIDi 5677263.
KEGGi aoe:Clos_2589.
PATRICi 20870658. VBIAlkOre124042_2706.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci AORE350688:GHBG-2702-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAsImported.

Entry informationi

Entry nameiA8MJY8_ALKOO
AccessioniPrimary (citable) accession number: A8MJY8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3