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Protein

Thymidine kinase

Gene

tdk

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25ATPUniRule annotation8
Nucleotide bindingi92 – 95ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciAORE350688:G1GAA-2752-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Clos_2589Imported
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))Imported
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000000269 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350688.Clos_2589

Structurei

3D structure databases

ProteinModelPortaliA8MJY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiCAGLDQD
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A8MJY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDFIEYSKG GSIEVIVGPM YAGKSEELMR RVNRCRIANL KVLSFKPAID
60 70 80 90 100
NRYSTNHITS HSGKQMECIP VSSPEEILGH LENKDFDVLA IDEVQFLGED
110 120 130 140 150
IVKICKDAAD MGKRVICSGL DMDFRGEPFQ VVPNLMAIAE YVTKLTAVCM
160 170 180 190
KCKVPATRTQ RIVNGKPAKY DDPIIMVGAK ESYEARCRAC HEVIK
Length:195
Mass (Da):21,790
Last modified:December 4, 2007 - v1
Checksum:iD607A4475268565F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA Translation: ABW20120.1
RefSeqiWP_012160427.1, NC_009922.1

Genome annotation databases

EnsemblBacteriaiABW20120; ABW20120; Clos_2589
KEGGiaoe:Clos_2589

Similar proteinsi

Entry informationi

Entry nameiA8MJY8_ALKOO
AccessioniPrimary (citable) accession number: A8MJY8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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