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A8MJY6

- SYL_ALKOO

UniProt

A8MJY6 - SYL_ALKOO

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Protein
Leucine--tRNA ligase
Gene
leuS, Clos_2587
Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAORE350688:GHBG-2700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Clos_2587
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Leucine--tRNA ligaseUniRule annotation
PRO_1000057340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_2587.

Structurei

3D structure databases

ProteinModelPortaliA8MJY6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotation
Add
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiNENGVEG.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MJY6-1 [UniParc]FASTAAdd to Basket

« Hide

MKQYNPKEIE SKWQNIWEER GVFHASNDKD KEKFYALIEF PYPSGQGLHV    50
GHPRPYTALD VVSRKRRLEG YNVLYPMGWD AFGLPTENYA IKNKIHPKVV 100
TEQNVARFKK QLQGLGMSFD WSREINTTDP EYYKWTQWIF LKLFEKGLAY 150
KKEMSINWCT SCKVGLANEE VVNGGCERCG AEVVRKQKNQ WMLKITEYAE 200
RLINDLDLVD YIERVKIQQK NWIGKSEGME VDFEITGGKK ITVYTTRPDT 250
LFGSTYMVIS PEHPYIEELA AHIQNMDDLV HYREEAAKKS EFERTELVKD 300
KTGVKIEGIE ATNPATGKQI PIFISDYVMM SYGTGAIMAV PGHDTRDWEF 350
AKKFNLPIVE VVSGGNVDEA AYTDTEEGII VNSDFINGMQ VKEAKEKISS 400
WLEEKGLGKR KVNYKLRDWV FSRQRYWGEP IPLVHCDCCG WVPVPESQLP 450
VLLPEVESYE PTDNGESPLA NLRDWVETTC PKCGGKAERE TDTMPQWAGS 500
SWYFLRYTDP HNNEELASKE NLDYWMPIDW YNGGMEHTTL HLLYSRFWHK 550
FLYDCGVVPS CEPYQKRTSH GMILGENNEK MSKSRGNVIN PDDIVTEFGA 600
DTLRLYEMFI GDFEKSVPWS QNGVKGCRRF LDRIWKLQEI LVDSQEMTKE 650
LEGNIHKTIK KVTEDYETLK FNTAVASMMA LINDFYDHGT VTKGDMKTLL 700
TLLNPVAPHI TEELWEVLGF EGHIYGTTWP IWDEAKTIDS VVEIPIQING 750
KVKGQMVISV DFTADQVKEQ FRNDERLMAL VEGKSIVKEI YVPGKIYNIV 800
VK 802
Length:802
Mass (Da):92,499
Last modified:December 4, 2007 - v1
Checksum:i96F021E311FB5EC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW20118.1.
RefSeqiYP_001514114.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW20118; ABW20118; Clos_2587.
GeneIDi5676663.
KEGGiaoe:Clos_2587.
PATRICi20870654. VBIAlkOre124042_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW20118.1 .
RefSeqi YP_001514114.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MJY6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 350688.Clos_2587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW20118 ; ABW20118 ; Clos_2587 .
GeneIDi 5676663.
KEGGi aoe:Clos_2587.
PATRICi 20870654. VBIAlkOre124042_2704.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi NENGVEG.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AORE350688:GHBG-2700-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiSYL_ALKOO
AccessioniPrimary (citable) accession number: A8MJY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi