Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8MJY6

- SYL_ALKOO

UniProt

A8MJY6 - SYL_ALKOO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAORE350688:GHBG-2700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Clos_2587
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Leucine--tRNA ligasePRO_1000057340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_2587.

Structurei

3D structure databases

ProteinModelPortaliA8MJY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiNENGVEG.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MJY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQYNPKEIE SKWQNIWEER GVFHASNDKD KEKFYALIEF PYPSGQGLHV
60 70 80 90 100
GHPRPYTALD VVSRKRRLEG YNVLYPMGWD AFGLPTENYA IKNKIHPKVV
110 120 130 140 150
TEQNVARFKK QLQGLGMSFD WSREINTTDP EYYKWTQWIF LKLFEKGLAY
160 170 180 190 200
KKEMSINWCT SCKVGLANEE VVNGGCERCG AEVVRKQKNQ WMLKITEYAE
210 220 230 240 250
RLINDLDLVD YIERVKIQQK NWIGKSEGME VDFEITGGKK ITVYTTRPDT
260 270 280 290 300
LFGSTYMVIS PEHPYIEELA AHIQNMDDLV HYREEAAKKS EFERTELVKD
310 320 330 340 350
KTGVKIEGIE ATNPATGKQI PIFISDYVMM SYGTGAIMAV PGHDTRDWEF
360 370 380 390 400
AKKFNLPIVE VVSGGNVDEA AYTDTEEGII VNSDFINGMQ VKEAKEKISS
410 420 430 440 450
WLEEKGLGKR KVNYKLRDWV FSRQRYWGEP IPLVHCDCCG WVPVPESQLP
460 470 480 490 500
VLLPEVESYE PTDNGESPLA NLRDWVETTC PKCGGKAERE TDTMPQWAGS
510 520 530 540 550
SWYFLRYTDP HNNEELASKE NLDYWMPIDW YNGGMEHTTL HLLYSRFWHK
560 570 580 590 600
FLYDCGVVPS CEPYQKRTSH GMILGENNEK MSKSRGNVIN PDDIVTEFGA
610 620 630 640 650
DTLRLYEMFI GDFEKSVPWS QNGVKGCRRF LDRIWKLQEI LVDSQEMTKE
660 670 680 690 700
LEGNIHKTIK KVTEDYETLK FNTAVASMMA LINDFYDHGT VTKGDMKTLL
710 720 730 740 750
TLLNPVAPHI TEELWEVLGF EGHIYGTTWP IWDEAKTIDS VVEIPIQING
760 770 780 790 800
KVKGQMVISV DFTADQVKEQ FRNDERLMAL VEGKSIVKEI YVPGKIYNIV

VK
Length:802
Mass (Da):92,499
Last modified:December 4, 2007 - v1
Checksum:i96F021E311FB5EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW20118.1.
RefSeqiYP_001514114.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW20118; ABW20118; Clos_2587.
GeneIDi5676663.
KEGGiaoe:Clos_2587.
PATRICi20870654. VBIAlkOre124042_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW20118.1 .
RefSeqi YP_001514114.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MJY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_2587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW20118 ; ABW20118 ; Clos_2587 .
GeneIDi 5676663.
KEGGi aoe:Clos_2587.
PATRICi 20870654. VBIAlkOre124042_2704.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi NENGVEG.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AORE350688:GHBG-2700-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiSYL_ALKOO
AccessioniPrimary (citable) accession number: A8MJY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3