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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
Gene namesi
Name:prfAUniRule annotation
Ordered Locus Names:Clos_2580
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000000269 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000576121 – 357Peptide chain release factor 1Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N5-methylglutamineUniRule annotation1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_2580.

Structurei

3D structure databases

ProteinModelPortaliA8MJX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
HOGENOMiHOG000074815.
KOiK02835.
OMAiNRLSEHR.
OrthoDBiPOG091H021P.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MJX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKLAFLEE KYEDLSEKIS EPEIINDQPQ WKKLVKEHSD LEEIVMKYRE
60 70 80 90 100
YKKTEQGLND AKEILRDKTA DEEFREMAKM EIAELEEKIE VLEGELKILL
110 120 130 140 150
LPKDPNDDKD VIVEIRAGAG GDEAGLFAAD LFRMYTRYAE NVGWKVEMMS
160 170 180 190 200
ANDTGIGGYK EVIFMIKGHG AYSRLKYESG VHRVQRIPST ESGGRIHTST
210 220 230 240 250
ITVAVLPEAD DVDFELDMND IRVDVFRSSG NGGQSVNTTD SAVRVTHIPT
260 270 280 290 300
GTVVSCQDEK SQLKNKEKAL KILRARLLDV LIQEQQAEIA QDRKSQVGTG
310 320 330 340 350
DRSERIRTYN FPQGRITDHR INVTLYRLDS FLNGDIQEMI DALITTDQAE

KLKEVNS
Length:357
Mass (Da):40,561
Last modified:December 4, 2007 - v1
Checksum:iCFC6C13BF57D44C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW20111.1.
RefSeqiWP_012160418.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW20111; ABW20111; Clos_2580.
KEGGiaoe:Clos_2580.
PATRICi20870638. VBIAlkOre124042_2696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW20111.1.
RefSeqiWP_012160418.1. NC_009922.1.

3D structure databases

ProteinModelPortaliA8MJX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350688.Clos_2580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW20111; ABW20111; Clos_2580.
KEGGiaoe:Clos_2580.
PATRICi20870638. VBIAlkOre124042_2696.

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
HOGENOMiHOG000074815.
KOiK02835.
OMAiNRLSEHR.
OrthoDBiPOG091H021P.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_ALKOO
AccessioniPrimary (citable) accession number: A8MJX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.