Reviewed, UniProtKB/Swiss-Prot A8MJ83 (PSD_ALKOO)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	Clos_2332

Organism

Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]

Taxonomic identifier

350688 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00663
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00663
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Phosphatidylserine decarboxylase beta chain By similarity		PRO_1000061926
	Chain	258 – 296	39	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_1000061927
Sites
	Site	257 – 258	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	258	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8MJ83-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: DA547B3360B7C98B	FASTA	296	34,074
	10 20 30 40 50 60 MKLYYIDRKT GERKEEIVAG DRYLKWMYGT ASGNSILELI AKKKIFSSVY GRLQDTSSSK 70 80 90 100 110 120 RKISRFIKEL QIDMDEAERR NPEEYKNFND FFARTLRKES RPITKDPEVL ISPADGRVFA 130 140 150 160 170 180 YEHIDMNKVV QVKGSTYRLM DLFQNNELAR EYDGGVCMVI RLCPADYHRF HFPDGGVVNY 190 200 210 220 230 240 TKKIEGNYYS VNPIALKKIA QIYCQNKREI SLFQSNNFGQ MVLMEVGATC VGSIVQTYKE 250 260 270 280 290 GQSVEKGEEK GYFKFGGSTV ILFLKKGAVK IDRDLIENTE KHIETKVHMG EGIGRI

References

[1]

"Complete genome of Alkaliphilus oremlandii OhILAs." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000853 Genomic DNA. Translation: ABW19865.1.
RefSeq	YP_001513861.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5677272.
GenomeReviews	Gene locus Clos_2332 in contig CP000853_GR.
KEGG	aoe:Clos_2332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	INQDEME.
Family and domain databases
HAMAP	MF_00663. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_ALKOO

Accession

Primary (citable) accession number: A8MJ83

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 4, 2007
Last modified:	November 3, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)