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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Clos_2127
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000000269 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000687881 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_2127.

Structurei

3D structure databases

ProteinModelPortaliA8MIN1.
SMRiA8MIN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MIN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDVQIAQE AKMLPIADIA AGLGIQDDEL ELYGKYKAKV SLDVFDRLKD
60 70 80 90 100
KPDGKLILVT AINPTPAGEG KTTTNVGLSM GLNKIGKKTI TALREPSLGP
110 120 130 140 150
NFGVKGGAAG GGYAQVVPME DINLHFTGDI HAITTAHNLL AALLDNHLHQ
160 170 180 190 200
GNKLNIDSRR IVWRRVLDMN DRALRNTVIG LGSRGDGVPR QDGFDITVAS
210 220 230 240 250
EIMAILCLSN SLEDLKDRIS RMVVAYNLDN QPITVNDLEA TGALSLLLKD
260 270 280 290 300
AIKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKLGLK LADYVVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRFAGL KPDCAVIVAT VRALKNHGGV PKAELNNENL
360 370 380 390 400
EALEKGYRNL EKHIENVQKF GVPAVVAINK FPTDTEAELN FLRKHCAEMG
410 420 430 440 450
AEVVLSDVWA NGGDGGIEMA KKVVEVVESK ESNFKPLYDV NASIVEKINT
460 470 480 490 500
IAKEVYGADG VDFTKSAQTQ IKKYEDLGLD KMPICMAKTQ YSLSDDPSLI
510 520 530 540 550
GRPSGFRITV KEIRLSAGAG FLVALTGDIM VMPGLPKVPA ANHMDILESG

EIIGLF
Length:556
Mass (Da):59,818
Last modified:December 4, 2007 - v1
Checksum:iC63A71BDB4F8CAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW19663.1.
RefSeqiWP_012159972.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW19663; ABW19663; Clos_2127.
KEGGiaoe:Clos_2127.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_ALKOO
AccessioniPrimary (citable) accession number: A8MIN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: July 5, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families