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A8MIN1

- FTHS_ALKOO

UniProt

A8MIN1 - FTHS_ALKOO

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Clos_2127
Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAORE350688:GHBG-2188-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Clos_2127
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000068788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350688.Clos_2127.

Structurei

3D structure databases

ProteinModelPortaliA8MIN1.
SMRiA8MIN1. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MIN1-1 [UniParc]FASTAAdd to Basket

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MKTDVQIAQE AKMLPIADIA AGLGIQDDEL ELYGKYKAKV SLDVFDRLKD    50
KPDGKLILVT AINPTPAGEG KTTTNVGLSM GLNKIGKKTI TALREPSLGP 100
NFGVKGGAAG GGYAQVVPME DINLHFTGDI HAITTAHNLL AALLDNHLHQ 150
GNKLNIDSRR IVWRRVLDMN DRALRNTVIG LGSRGDGVPR QDGFDITVAS 200
EIMAILCLSN SLEDLKDRIS RMVVAYNLDN QPITVNDLEA TGALSLLLKD 250
AIKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKLGLK LADYVVTEAG 300
FGADLGAEKF FDIKCRFAGL KPDCAVIVAT VRALKNHGGV PKAELNNENL 350
EALEKGYRNL EKHIENVQKF GVPAVVAINK FPTDTEAELN FLRKHCAEMG 400
AEVVLSDVWA NGGDGGIEMA KKVVEVVESK ESNFKPLYDV NASIVEKINT 450
IAKEVYGADG VDFTKSAQTQ IKKYEDLGLD KMPICMAKTQ YSLSDDPSLI 500
GRPSGFRITV KEIRLSAGAG FLVALTGDIM VMPGLPKVPA ANHMDILESG 550
EIIGLF 556
Length:556
Mass (Da):59,818
Last modified:December 4, 2007 - v1
Checksum:iC63A71BDB4F8CAA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW19663.1.
RefSeqiYP_001513659.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW19663; ABW19663; Clos_2127.
GeneIDi5676638.
KEGGiaoe:Clos_2127.
PATRICi20869616. VBIAlkOre124042_2234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW19663.1 .
RefSeqi YP_001513659.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MIN1.
SMRi A8MIN1. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_2127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW19663 ; ABW19663 ; Clos_2127 .
GeneIDi 5676638.
KEGGi aoe:Clos_2127.
PATRICi 20869616. VBIAlkOre124042_2234.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci AORE350688:GHBG-2188-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiFTHS_ALKOO
AccessioniPrimary (citable) accession number: A8MIN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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