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A8MIN1

- FTHS_ALKOO

UniProt

A8MIN1 - FTHS_ALKOO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAORE350688:GHBG-2188-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Clos_2127
    OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
    Taxonomic identifieri350688 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
    ProteomesiUP000000269: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000068788Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350688.Clos_2127.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MIN1.
    SMRiA8MIN1. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIPRESGF.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MIN1-1 [UniParc]FASTAAdd to Basket

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    MKTDVQIAQE AKMLPIADIA AGLGIQDDEL ELYGKYKAKV SLDVFDRLKD    50
    KPDGKLILVT AINPTPAGEG KTTTNVGLSM GLNKIGKKTI TALREPSLGP 100
    NFGVKGGAAG GGYAQVVPME DINLHFTGDI HAITTAHNLL AALLDNHLHQ 150
    GNKLNIDSRR IVWRRVLDMN DRALRNTVIG LGSRGDGVPR QDGFDITVAS 200
    EIMAILCLSN SLEDLKDRIS RMVVAYNLDN QPITVNDLEA TGALSLLLKD 250
    AIKPNLVQTL ENTPAFIHGG PFANIAHGCN SVLATKLGLK LADYVVTEAG 300
    FGADLGAEKF FDIKCRFAGL KPDCAVIVAT VRALKNHGGV PKAELNNENL 350
    EALEKGYRNL EKHIENVQKF GVPAVVAINK FPTDTEAELN FLRKHCAEMG 400
    AEVVLSDVWA NGGDGGIEMA KKVVEVVESK ESNFKPLYDV NASIVEKINT 450
    IAKEVYGADG VDFTKSAQTQ IKKYEDLGLD KMPICMAKTQ YSLSDDPSLI 500
    GRPSGFRITV KEIRLSAGAG FLVALTGDIM VMPGLPKVPA ANHMDILESG 550
    EIIGLF 556
    Length:556
    Mass (Da):59,818
    Last modified:December 4, 2007 - v1
    Checksum:iC63A71BDB4F8CAA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000853 Genomic DNA. Translation: ABW19663.1.
    RefSeqiYP_001513659.1. NC_009922.1.

    Genome annotation databases

    EnsemblBacteriaiABW19663; ABW19663; Clos_2127.
    GeneIDi5676638.
    KEGGiaoe:Clos_2127.
    PATRICi20869616. VBIAlkOre124042_2234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000853 Genomic DNA. Translation: ABW19663.1 .
    RefSeqi YP_001513659.1. NC_009922.1.

    3D structure databases

    ProteinModelPortali A8MIN1.
    SMRi A8MIN1. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350688.Clos_2127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW19663 ; ABW19663 ; Clos_2127 .
    GeneIDi 5676638.
    KEGGi aoe:Clos_2127.
    PATRICi 20869616. VBIAlkOre124042_2234.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IPRESGF.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci AORE350688:GHBG-2188-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OhILAs.

    Entry informationi

    Entry nameiFTHS_ALKOO
    AccessioniPrimary (citable) accession number: A8MIN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3