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A8MH36 (MURG_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:Clos_1379
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000057244

Sequences

Sequence LengthMass (Da)Tools
A8MH36 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: A6AA7C8BBB741330

FASTA36640,253
        10         20         30         40         50         60 
MRVILSGGGT GGHIYPAISI ANKIKEQHPK AEILFIGTEN GMESEIVPKA GYPIKYVTVS 

        70         80         90        100        110        120 
YLKRKISLHN VKSAAMLLKG IAEARKIIKE FKPDIVIGTG GFVCGPVLYM ASKLGIRTMI 

       130        140        150        160        170        180 
HEQNVFPGLT NRILDRYVDR IALSFKDAEK YFKHKNKLVV TGNPIRSDFM EVTEVEASAR 

       190        200        210        220        230        240 
YKTDSDLPLV LVVGGSGGAL KINRAVVEIL NQYQPNKYRL LLVTGKRLYK STLESINAES 

       250        260        270        280        290        300 
LQSKHKVFAY VNDMPHALKA CDLIVCSAGA ITIAEVTAVG KASILIPKAH TAENHQEYNA 

       310        320        330        340        350        360 
NAMGNKGAAV VIREDELSGE ILNKKIQDII GNIQVVKKME AASYKEGIRD AADRIYSEMQ 


ALLERK

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References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000853 Genomic DNA. Translation: ABW18923.1.
RefSeqYP_001512919.1. NC_009922.1.

3D structure databases

ProteinModelPortalA8MH36.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8MH36.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5675908.
GenomeReviewsGene locus Clos_1379 in contig CP000853_GR.
KEGGaoe:Clos_1379.
PATRIC20867983. VBIAlkOre124042_1448.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycAORE350688:CLOS_1379-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_ALKOO
AccessionPrimary (citable) accession number: A8MH36
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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