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A8MH16 (AROA_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Clos_1359
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4274273-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000058593

Sequences

Sequence LengthMass (Da)Tools
A8MH16 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 5F60CBBD7EAAC164

FASTA42746,541
        10         20         30         40         50         60 
MDFVVNKIEA ISGSVKVPGD KSISHRSIIL GSISKGTTYV RDILLSEDVQ RTIGFFKKLG 

        70         80         90        100        110        120 
VSIEQKNKVI ALKGMAIEDF RPYTQELDMG NSGTSARLLL GLISGSPHAY VLNGDPFLKK 

       130        140        150        160        170        180 
RPMKRVTKPL EQMGAHIEYL EREDLLPIKI KGGNLRGIHY KLPVASAQIK SALILAGLHC 

       190        200        210        220        230        240 
SGKTVIEEPV ATRDHTEIMI QHFGGTVEKN NHFIQIKGNQ RLLANEVLVP GDISSAAFLL 

       250        260        270        280        290        300 
VLSAIVPKAE LMIEDVGLNP TRSGILHVLE SMGARMEILE ERVVNGERVG NILIRHSCLK 

       310        320        330        340        350        360 
AVTIEGDIIP TLIDEIPILA VAATQAEGIT VIRDAQELKV KESNRIDTVV SQLKKMGANI 

       370        380        390        400        410        420 
EASHDGMIIQ GPTKLKGATI DSEFDHRIAM AFAVAGMVAE GETKILKSEC IAVSFPEFTE 


ILKKISK

« Hide

References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000853 Genomic DNA. Translation: ABW18903.1.
RefSeqYP_001512899.1. NC_009922.1.

3D structure databases

ProteinModelPortalA8MH16.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8MH16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5677505.
GenomeReviewsGene locus Clos_1359 in contig CP000853_GR.
KEGGaoe:Clos_1359.
PATRIC20867943. VBIAlkOre124042_1428.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG646626.
OMALECANIS.

Enzyme and pathway databases

BioCycAORE350688:CLOS_1359-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_ALKOO
AccessionPrimary (citable) accession number: A8MH16
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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