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A8MH15 (AROB_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Clos_1358
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3633633-dehydroquinate synthase HAMAP MF_00110
PRO_1000094451

Sequences

Sequence LengthMass (Da)Tools
A8MH15 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 109E2470822E77FF

FASTA36341,473
        10         20         30         40         50         60 
MLETKINLGK VTYPLYMGRN LLDNLDVLIE DHIEGKTVFL LTEDNVFKYY GNPLLEKLKS 

        70         80         90        100        110        120 
SRFKYHIIES GETSKSIDTY GEIIHELTEN KQDRDTIILA LGGGVIGDLG GFVASTYMRG 

       130        140        150        160        170        180 
VDLIHIPTTL LAQIDSSIGG KTGINFGAIK NLLGTFYHPR AVYMDLSTLD TLPKREYIAA 

       190        200        210        220        230        240 
FGEIIKYGLI GDYDLLLDLD QHHRAYLDRT RSVDDLILKC IRMKENIVLK DERDSGMRQV 

       250        260        270        280        290        300 
LNLGHTFAHG LESSTNFQKF LHGEAVALGL IFASNLSLKL KFIAEEYHQF VNQLIYKYFS 

       310        320        330        340        350        360 
DRYILQLDTE GIVEAMTMDK KNKEHRITFI LPVDKEKVEI FKNIPIEIVE ESLEEIKYGF 


RCK

« Hide

References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000853 Genomic DNA. Translation: ABW18902.1.
RefSeqYP_001512898.1. NC_009922.1.

3D structure databases

ProteinModelPortalA8MH15.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8MH15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5677504.
GenomeReviewsGene locus Clos_1358 in contig CP000853_GR.
KEGGaoe:Clos_1358.
PATRIC20867941. VBIAlkOre124042_1427.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAHATIVED.

Enzyme and pathway databases

BioCycAORE350688:CLOS_1358-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ALKOO
AccessionPrimary (citable) accession number: A8MH15
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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