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A8MH14 (AROC_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Clos_1357
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Chorismate synthase HAMAP MF_00300
PRO_0000322385

Sequences

Sequence LengthMass (Da)Tools
A8MH14 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 7B2C2736D2106F59

FASTA38442,764
        10         20         30         40         50         60 
MLRYLSAGES HGKGLIAIIE GLPSNIPMDI NRINADLGRR QQGFGRGNRM KIEKDRVEIL 

        70         80         90        100        110        120 
SGVRDGKTLG TPLTLMIENL DYKNWTSIMS VEKLEKQNII VEPRPGHGDL VGSLKYNHKD 

       130        140        150        160        170        180 
IRNVIERTSA RDTAIRTAIG AVVKQFLSIF DIEILSHVIS IGRAHYVPFV EDLFQYKSQI 

       190        200        210        220        230        240 
EASPVRCLNP TIEERMMGEI QRAKETGDSL GGVFEVIVRN VPIGIGSYAH FDRKLDGILA 

       250        260        270        280        290        300 
QGLMSLQAIK AVEIGNGIEG SSKMGSQFHD EIKYSEAKGY YHDTNRAGGI EAGVSNGEDI 

       310        320        330        340        350        360 
LIRGYMKPIP TLMKPLKTVD MGTKEVKEAI IERSDNCAVP SAAVVAEGIC AFAIAKEFLE 

       370        380 
KFRGDSIEEV EWNYERYMNY LRSR

« Hide

References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000853 Genomic DNA. Translation: ABW18901.1.
RefSeqYP_001512897.1. NC_009922.1.

3D structure databases

ProteinModelPortalA8MH14.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8MH14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5677503.
GenomeReviewsGene locus Clos_1357 in contig CP000853_GR.
KEGGaoe:Clos_1357.
PATRIC20867939. VBIAlkOre124042_1426.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycAORE350688:CLOS_1357-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ALKOO
AccessionPrimary (citable) accession number: A8MH14
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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