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Protein

Glycerol kinase

Gene

glpK

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei309ATP; via carbonyl oxygenUniRule annotation1
Binding sitei313ATP; via amide nitrogenUniRule annotation1
Binding sitei328ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi410 – 414ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAORE350688:G1GAA-1040-MONOMER
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Clos_1002
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000000269 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000584431 – 504Glycerol kinaseAdd BLAST504

Proteomic databases

PRIDEiA8MG11

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium).UniRule annotation

Protein-protein interaction databases

STRINGi350688.Clos_1002

Structurei

3D structure databases

ProteinModelPortaliA8MG11
SMRiA8MG11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 83Substrate bindingUniRule annotation2
Regioni244 – 245Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HMR Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ
OrthoDBiPOG091H02FA

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8MG11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYVMALDQ GTTSSRAILF DYEGKIVATS QKEFTQIYPK AGWVEHDPME
60 70 80 90 100
IWGTQSGVAR EVLERMAISP QDIAAIGITN QRETTIVWDK NTGKPVYNAI
110 120 130 140 150
VWQCRRTAAI CDELKTQGMA DYIRENTGLV LDAYFSGTKI KWILDHVEGA
160 170 180 190 200
KEKAEKGELL FGTVDSWLIW NLTRGKVHVT DYSNASRTML YNIKQLKWDD
210 220 230 240 250
KILKALEIPK SMLPEVKESS AIYGYTDHQT FGGADIPIAG AAGDQQAALF
260 270 280 290 300
GQGCFKEGMG KNTYGTGCFM LMNTGDQFVQ SKNGLLTTLA WGIDGKVEYA
310 320 330 340 350
LEGSIFVAGA SVQWLRDELK IIRDAEDTEY LAKKVPNSNG VYVVPAFTGM
360 370 380 390 400
GAPYWDMYAR GAIVGLTRGA KAEHIIRATL ESIAYQTRDV LEAMEQDSGI
410 420 430 440 450
QLKSLKVDGG AAMNNFLMQF QADILSVPVD RPKITETTAL GAAYLAGLAV
460 470 480 490 500
GFWKDKNEIE SKWSVDTVFE PGMDHEEKER LYKGWKRAVN RALKWEEENE

LDVK
Length:504
Mass (Da):56,167
Last modified:December 4, 2007 - v1
Checksum:i453A83872FCEE745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA Translation: ABW18549.1
RefSeqiWP_012158861.1, NC_009922.1

Genome annotation databases

EnsemblBacteriaiABW18549; ABW18549; Clos_1002
KEGGiaoe:Clos_1002

Similar proteinsi

Entry informationi

Entry nameiGLPK_ALKOO
AccessioniPrimary (citable) accession number: A8MG11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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