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A8MFV5 (UPPP_ALKOO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Clos_0946
OrganismAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs)) [Complete proteome] [HAMAP]
Taxonomic identifier350688 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062785

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane252 – 27221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8MFV5 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 6FEB7A7909EA2AAD

FASTA27931,372
        10         20         30         40         50         60 
MSIIELLKVI FLGIVEGITE WLPISSTGHM ILVEEFIQLN ASAAFKEMFF VVVQLGAIMA 

        70         80         90        100        110        120 
VVLLYFNKLN PFALSKTKRE KRETMRIWYK VVVGIIPAGV MGLLFDDWLN EHLYNYWTVA 

       130        140        150        160        170        180 
AMLIVYGVLF IIIENRNKHR YAKINSFSEL SYSTAFLIGL FQVLSLIPGT SRSGATIIGA 

       190        200        210        220        230        240 
IILGTSRYIA AEYSFFMSIP IMFGASAVKL LKFGFNFTSI EIITLVTGMV VAFVVSIIAI 

       250        260        270 
RLLMAYIKNN DFKAFGWYRI FLGVVVIGYF LITNGKVLS 

« Hide

References

[1]"Complete genome of Alkaliphilus oremlandii OhILAs."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E., Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OhILAs.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000853 Genomic DNA. Translation: ABW18493.1.
RefSeqYP_001512489.1. NC_009922.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING350688.Clos_0946.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW18493; ABW18493; Clos_0946.
GeneID5676488.
KEGGaoe:Clos_0946.
PATRIC20867051. VBIAlkOre124042_0986.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycAORE350688:GHBG-970-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ALKOO
AccessionPrimary (citable) accession number: A8MFV5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families