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Protein

8-amino-7-oxononanoate synthase

Gene

Clos_0909

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateBy similarity1
Binding sitei136SubstrateBy similarity1
Binding sitei184Pyridoxal phosphateBy similarity1
Binding sitei357SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:Clos_0909
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000000269 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003808931 – 3958-amino-7-oxononanoate synthaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi350688.Clos_0909.

Structurei

3D structure databases

ProteinModelPortaliA8MEX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 112Pyridoxal phosphate bindingBy similarity2
Regioni209 – 212Pyridoxal phosphate bindingBy similarity4
Regioni240 – 243Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiQYVIDAF.
OrthoDBiPOG091H024U.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MEX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVHELNFL KEKIQELKDQ GVYRQLPVLE GPNEAESILN GKKVINLSSN
60 70 80 90 100
NYLGFANHPR LKKAAIEAVE KYGVGSGAVR TIVGNMDIHE ILDKKLAEFK
110 120 130 140 150
REEAVMSFQS GFNCNAGTIQ AITEKGDLII SDELNHASII DGARLSRADK
160 170 180 190 200
TIFKHADMNN LEEVLKANRD KYRNMLIITD GVFSMDGDIA PLPDIVGLAE
210 220 230 240 250
KYNAMTYVDD AHGSGVLGES GRGTVDHFGL HGRVDFTIGT LSKAIGVVGG
260 270 280 290 300
YVAGSATMRD WLSHRGRPLL FSTSLPPAAI AAITEAINML MTTTEYTDRL
310 320 330 340 350
WDNAKYFKAK MSQLGFNIGN SQTPITPVII GDEAKTMEFS RKLLENGVFV
360 370 380 390
SAIVFPTVPK GTGRLRCMVT AGHTKEQLDR AVETFKKVGE EMNLL
Length:395
Mass (Da):43,281
Last modified:December 4, 2007 - v1
Checksum:iB4D3D9D35CFAAD04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW18456.1.
RefSeqiWP_012158768.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW18456; ABW18456; Clos_0909.
KEGGiaoe:Clos_0909.
PATRICi20866977. VBIAlkOre124042_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW18456.1.
RefSeqiWP_012158768.1. NC_009922.1.

3D structure databases

ProteinModelPortaliA8MEX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350688.Clos_0909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW18456; ABW18456; Clos_0909.
KEGGiaoe:Clos_0909.
PATRICi20866977. VBIAlkOre124042_0949.

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiQYVIDAF.
OrthoDBiPOG091H024U.

Enzyme and pathway databases

UniPathwayiUPA00078.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOF_ALKOO
AccessioniPrimary (citable) accession number: A8MEX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.