Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8MEG7

- GCSPB_ALKOO

UniProt

A8MEG7 - GCSPB_ALKOO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAORE350688:GHBG-83-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Clos_0068
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000062080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi350688.Clos_0068.

Structurei

3D structure databases

ProteinModelPortaliA8MEG7.
SMRiA8MEG7. Positions 7-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MEG7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDYNKLIF EISKEGRKAY SLPKCDVEEV NLESLIPKEF LSDKELDLPE
60 70 80 90 100
VSEVDVIRHY TQLSNKNYGV DTGFYPLGSC TMKYNPKLNE DMAVLPGFAN
110 120 130 140 150
IHPYQPEETV QGALELMYKL DKMLAEVAGM ERMTLQPAAG AHGELVGLMV
160 170 180 190 200
IKAYHKKRGD LKRTKIIIPD SAHGTNPASA AVAGFDVVEI KSNPDGSVNI
210 220 230 240 250
DSLKSALSDE IAGLMLTNPS TLGLFETNIK QIADLVHDAG GLLYYDGANM
260 270 280 290 300
NAIMGVTRPG DMGFDVIHYN IHKTFSTPHG GGGPGSGPVG VRKDLVEFLP
310 320 330 340 350
SPVIEKKGEE YVLDYDRPYS IGKIKSFYGH FGILVRAYTY ILSYGPALRE
360 370 380 390 400
VSEKAVLNAN YMMHKLKEKY YLPIEQVCKH EFVLGGLNED ILGVSTLDIA
410 420 430 440 450
KRLLDYGYHP PTIYFPLIVN EAMMIEPTET ESVETLDQFI DALNKIADEA
460 470 480
KETPELLKNA PHHTHVRRID EAKAARNLIV KWEREQ
Length:486
Mass (Da):54,111
Last modified:December 4, 2007 - v1
Checksum:iF4CF441B7DFB1782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW17638.1.
RefSeqiYP_001511634.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW17638; ABW17638; Clos_0068.
GeneIDi5675981.
KEGGiaoe:Clos_0068.
PATRICi20865204. VBIAlkOre124042_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000853 Genomic DNA. Translation: ABW17638.1 .
RefSeqi YP_001511634.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MEG7.
SMRi A8MEG7. Positions 7-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_0068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW17638 ; ABW17638 ; Clos_0068 .
GeneIDi 5675981.
KEGGi aoe:Clos_0068.
PATRICi 20865204. VBIAlkOre124042_0073.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AORE350688:GHBG-83-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiGCSPB_ALKOO
AccessioniPrimary (citable) accession number: A8MEG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3