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A8MEG7

- GCSPB_ALKOO

UniProt

A8MEG7 - GCSPB_ALKOO

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, Clos_0068
Organism
Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAORE350688:GHBG-83-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Clos_0068
OrganismiAlkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain OhILAs))
Taxonomic identifieri350688 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000000269: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000062080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi350688.Clos_0068.

Structurei

3D structure databases

ProteinModelPortaliA8MEG7.
SMRiA8MEG7. Positions 7-483.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MEG7-1 [UniParc]FASTAAdd to Basket

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MKSDYNKLIF EISKEGRKAY SLPKCDVEEV NLESLIPKEF LSDKELDLPE    50
VSEVDVIRHY TQLSNKNYGV DTGFYPLGSC TMKYNPKLNE DMAVLPGFAN 100
IHPYQPEETV QGALELMYKL DKMLAEVAGM ERMTLQPAAG AHGELVGLMV 150
IKAYHKKRGD LKRTKIIIPD SAHGTNPASA AVAGFDVVEI KSNPDGSVNI 200
DSLKSALSDE IAGLMLTNPS TLGLFETNIK QIADLVHDAG GLLYYDGANM 250
NAIMGVTRPG DMGFDVIHYN IHKTFSTPHG GGGPGSGPVG VRKDLVEFLP 300
SPVIEKKGEE YVLDYDRPYS IGKIKSFYGH FGILVRAYTY ILSYGPALRE 350
VSEKAVLNAN YMMHKLKEKY YLPIEQVCKH EFVLGGLNED ILGVSTLDIA 400
KRLLDYGYHP PTIYFPLIVN EAMMIEPTET ESVETLDQFI DALNKIADEA 450
KETPELLKNA PHHTHVRRID EAKAARNLIV KWEREQ 486
Length:486
Mass (Da):54,111
Last modified:December 4, 2007 - v1
Checksum:iF4CF441B7DFB1782
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW17638.1.
RefSeqiYP_001511634.1. NC_009922.1.

Genome annotation databases

EnsemblBacteriaiABW17638; ABW17638; Clos_0068.
GeneIDi5675981.
KEGGiaoe:Clos_0068.
PATRICi20865204. VBIAlkOre124042_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000853 Genomic DNA. Translation: ABW17638.1 .
RefSeqi YP_001511634.1. NC_009922.1.

3D structure databases

ProteinModelPortali A8MEG7.
SMRi A8MEG7. Positions 7-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350688.Clos_0068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW17638 ; ABW17638 ; Clos_0068 .
GeneIDi 5675981.
KEGGi aoe:Clos_0068.
PATRICi 20865204. VBIAlkOre124042_0073.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AORE350688:GHBG-83-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OhILAs.

Entry informationi

Entry nameiGCSPB_ALKOO
AccessioniPrimary (citable) accession number: A8MEG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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