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A8MDU6

- DNLI_CALMQ

UniProt

A8MDU6 - DNLI_CALMQ

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Protein

DNA ligase

Gene

lig

Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei262 – 2621ATPUniRule annotation
Active sitei264 – 2641N6-AMP-lysine intermediateUniRule annotation
Binding sitei269 – 2691ATPUniRule annotation
Binding sitei285 – 2851ATPUniRule annotation
Binding sitei315 – 3151ATPUniRule annotation
Binding sitei355 – 3551ATPUniRule annotation
Binding sitei432 – 4321ATPUniRule annotation
Binding sitei438 – 4381ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Cmaq_1124
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
ProteomesiUP000001137: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603DNA ligasePRO_0000365243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397948.Cmaq_1124.

Structurei

3D structure databases

ProteinModelPortaliA8MDU6.
SMRiA8MDU6. Positions 5-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MDU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESDLEFSNI VSVLKLVEAT TQRTVMAKAL SSLLAKTPPQ VIDKVIYFLL
60 70 80 90 100
GSLRPDWEGV ELGLAERLTL RAISMATGLP IRQVEELYKK LGDAGEVAKR
110 120 130 140 150
AAEIKRSKGG GGTIFDFIDT GPKRRLTISK VYDTLMAIAK ASGEGAQDTK
160 170 180 190 200
VKLLSSLLTD AEPDEAKYIT RFVIGRLRLG VADMTILDAL SDAFDVNRDL
210 220 230 240 250
LEKAYHVYPD LGKIAKTLAE GGEEAVKAIK VTPGVPIQPM LAERLSSPKE
260 270 280 290 300
ILNKLGGVAI CEFKYDGERM QIHKLKDGTV KIFSRRMEDI TNQYPDVAEY
310 320 330 340 350
AREAIDAEEF IVEGEGVAID PDTGEFKPFQ ELMHRKRKHN IKEAIEEYPI
360 370 380 390 400
NLYLFDVMYV NGQDLTDLPL PDRKKVLFSI IKPHEHVHHA DWIITDDADS
410 420 430 440 450
LEKFFLDAIS SGCEGVMCKS VKLGSVYEMG ARGWLWIKYK RDYKSELSDT
460 470 480 490 500
MDLVVVGAFW GRGKRAGTYG ALLLAAYDPD SDQFYTVCKV GSGFTDEDLK
510 520 530 540 550
KLPQMLEPYK IPHRHPRVVS KMEPDIWFTP GLVLEITGAE ITMSPLHTCC
560 570 580 590 600
SVMLKGDVGL AIRFPRFTGR YRTDKRPEDA TTVKEIFEMY SNQKKVKLTD

QVP
Length:603
Mass (Da):67,561
Last modified:December 4, 2007 - v1
Checksum:i616703AB3A417D84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW01952.1.
RefSeqiYP_001540942.1. NC_009954.1.

Genome annotation databases

EnsemblBacteriaiABW01952; ABW01952; Cmaq_1124.
GeneIDi5710004.
KEGGicma:Cmaq_1124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW01952.1 .
RefSeqi YP_001540942.1. NC_009954.1.

3D structure databases

ProteinModelPortali A8MDU6.
SMRi A8MDU6. Positions 5-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 397948.Cmaq_1124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW01952 ; ABW01952 ; Cmaq_1124 .
GeneIDi 5710004.
KEGGi cma:Cmaq_1124.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci CMAQ397948:GH9M-1148-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Entry informationi

Entry nameiDNLI_CALMQ
AccessioniPrimary (citable) accession number: A8MDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3