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A8MDU6 (DNLI_CALMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Cmaq_1124
OrganismCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]
Taxonomic identifier397948 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 603603DNA ligase HAMAP-Rule MF_00407
PRO_0000365243

Sites

Active site2641N6-AMP-lysine intermediate By similarity
Binding site2621ATP By similarity
Binding site2691ATP By similarity
Binding site2851ATP By similarity
Binding site3151ATP By similarity
Binding site3551ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MDU6 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 616703AB3A417D84

FASTA60367,561
        10         20         30         40         50         60 
MESDLEFSNI VSVLKLVEAT TQRTVMAKAL SSLLAKTPPQ VIDKVIYFLL GSLRPDWEGV 

        70         80         90        100        110        120 
ELGLAERLTL RAISMATGLP IRQVEELYKK LGDAGEVAKR AAEIKRSKGG GGTIFDFIDT 

       130        140        150        160        170        180 
GPKRRLTISK VYDTLMAIAK ASGEGAQDTK VKLLSSLLTD AEPDEAKYIT RFVIGRLRLG 

       190        200        210        220        230        240 
VADMTILDAL SDAFDVNRDL LEKAYHVYPD LGKIAKTLAE GGEEAVKAIK VTPGVPIQPM 

       250        260        270        280        290        300 
LAERLSSPKE ILNKLGGVAI CEFKYDGERM QIHKLKDGTV KIFSRRMEDI TNQYPDVAEY 

       310        320        330        340        350        360 
AREAIDAEEF IVEGEGVAID PDTGEFKPFQ ELMHRKRKHN IKEAIEEYPI NLYLFDVMYV 

       370        380        390        400        410        420 
NGQDLTDLPL PDRKKVLFSI IKPHEHVHHA DWIITDDADS LEKFFLDAIS SGCEGVMCKS 

       430        440        450        460        470        480 
VKLGSVYEMG ARGWLWIKYK RDYKSELSDT MDLVVVGAFW GRGKRAGTYG ALLLAAYDPD 

       490        500        510        520        530        540 
SDQFYTVCKV GSGFTDEDLK KLPQMLEPYK IPHRHPRVVS KMEPDIWFTP GLVLEITGAE 

       550        560        570        580        590        600 
ITMSPLHTCC SVMLKGDVGL AIRFPRFTGR YRTDKRPEDA TTVKEIFEMY SNQKKVKLTD 


QVP 

« Hide

References

[1]"Complete sequence of Caldivirga maquilingensis IC-167."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000852 Genomic DNA. Translation: ABW01952.1.
RefSeqYP_001540942.1. NC_009954.1.

3D structure databases

ProteinModelPortalA8MDU6.
SMRA8MDU6. Positions 5-595.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397948.Cmaq_1124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW01952; ABW01952; Cmaq_1124.
GeneID5710004.
KEGGcma:Cmaq_1124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAMVKMLEG.

Enzyme and pathway databases

BioCycCMAQ397948:GH9M-1148-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_CALMQ
AccessionPrimary (citable) accession number: A8MDU6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families