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Protein

DNA ligase

Gene

lig

Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei262ATPUniRule annotation1
Active sitei264N6-AMP-lysine intermediateUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei285ATPUniRule annotation1
Binding sitei315ATPUniRule annotation1
Binding sitei355ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMAQ397948:G1GA9-1157-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Cmaq_1124
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
Proteomesi
  • UP000001137 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652431 – 603DNA ligaseAdd BLAST603

Interactioni

Protein-protein interaction databases

STRINGi397948.Cmaq_1124

Structurei

3D structure databases

ProteinModelPortaliA8MDU6
SMRiA8MDU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A8MDU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESDLEFSNI VSVLKLVEAT TQRTVMAKAL SSLLAKTPPQ VIDKVIYFLL
60 70 80 90 100
GSLRPDWEGV ELGLAERLTL RAISMATGLP IRQVEELYKK LGDAGEVAKR
110 120 130 140 150
AAEIKRSKGG GGTIFDFIDT GPKRRLTISK VYDTLMAIAK ASGEGAQDTK
160 170 180 190 200
VKLLSSLLTD AEPDEAKYIT RFVIGRLRLG VADMTILDAL SDAFDVNRDL
210 220 230 240 250
LEKAYHVYPD LGKIAKTLAE GGEEAVKAIK VTPGVPIQPM LAERLSSPKE
260 270 280 290 300
ILNKLGGVAI CEFKYDGERM QIHKLKDGTV KIFSRRMEDI TNQYPDVAEY
310 320 330 340 350
AREAIDAEEF IVEGEGVAID PDTGEFKPFQ ELMHRKRKHN IKEAIEEYPI
360 370 380 390 400
NLYLFDVMYV NGQDLTDLPL PDRKKVLFSI IKPHEHVHHA DWIITDDADS
410 420 430 440 450
LEKFFLDAIS SGCEGVMCKS VKLGSVYEMG ARGWLWIKYK RDYKSELSDT
460 470 480 490 500
MDLVVVGAFW GRGKRAGTYG ALLLAAYDPD SDQFYTVCKV GSGFTDEDLK
510 520 530 540 550
KLPQMLEPYK IPHRHPRVVS KMEPDIWFTP GLVLEITGAE ITMSPLHTCC
560 570 580 590 600
SVMLKGDVGL AIRFPRFTGR YRTDKRPEDA TTVKEIFEMY SNQKKVKLTD

QVP
Length:603
Mass (Da):67,561
Last modified:December 4, 2007 - v1
Checksum:i616703AB3A417D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000852 Genomic DNA Translation: ABW01952.1
RefSeqiWP_012186171.1, NC_009954.1

Genome annotation databases

EnsemblBacteriaiABW01952; ABW01952; Cmaq_1124
GeneIDi5710004
KEGGicma:Cmaq_1124

Similar proteinsi

Entry informationi

Entry nameiDNLI_CALMQ
AccessioniPrimary (citable) accession number: A8MDU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health