A8MCA2 (A8MCA2_CALMQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208

Gene names

Name:	pyrE HAMAP MF_01208
Ordered Locus Names:	Cmaq_0565

Organism

Caldivirga maquilingensis (strain ATCC 700844 / DSMZ 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]

Taxonomic identifier

397948 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Caldivirga

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity. HAMAP MF_01208
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity. HAMAP MF_01208
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_01208
Ligand	Magnesium HAMAP MF_01208
Molecular function	Glycosyltransferase HAMAP MF_01208 EMBL ABW01408.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	114 – 122	9	5-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208
Sites
	Binding site	88	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
	Binding site	89	1	5-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
	Binding site	92	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
	Binding site	94	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
	Binding site	118	1	Orotate By similarity HAMAP MF_01208
	Binding site	146	1	Orotate By similarity HAMAP MF_01208

Sequences

	Sequence		Length	Mass (Da)
	A8MCA2 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 00808BDBE3D7CFD8	FASTA	181	19,860
	10 20 30 40 50 60 MSIELARLLV KYGVVKFGDF TLSSGVKSKY YVDMRMAISI PEVYKPIIEE LALRIGGGID 70 80 90 100 110 120 LIAGIESGSI PWASMLAYRL SKGTLYVRKA DKSHGTRRRI EGYYKGGEGV LLIDDVVTTG 130 140 150 160 170 180 GTILDSIRVL EENGLRVIEV AVIVDRLEGG LDAIRRSGYR AWSLLTVKDL FNAMGISNAT Q

References

[1]

"Complete sequence of Caldivirga maquilingensis IC-167." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700844 / DSMZ 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000852 Genomic DNA. Translation: ABW01408.1.
RefSeq	YP_001540398.1. NC_009954.1.
3D structure databases
ProteinModelPortal	A8MCA2.
ModBase	Search...
Protein-protein interaction databases
STRING	A8MCA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5708601.
GenomeReviews	Gene locus Cmaq_0565 in contig CP000852_GR.
KEGG	cma:Cmaq_0565.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG404341.
OMA	QTCLVIN.
Family and domain databases
HAMAP	MF_01208. PyrE. [Tree]
InterPro	IPR004467. Or_phspho_trans_clade-1. IPR023031. Orotate_PribosylTferase. IPR000836. PRibTrfase. [Graphical view]
KO	K00762.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR00336. PyrE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8MCA2_CALMQ

Accession

Primary (citable) accession number: A8MCA2

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)