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A8MC60 (GCH1_CALMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:Cmaq_0521
OrganismCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]
Taxonomic identifier397948 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000100165

Sites

Metal binding731Zinc By similarity
Metal binding761Zinc By similarity
Metal binding1441Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MC60 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 0F07E510A1E8467D

FASTA18821,219
        10         20         30         40         50         60 
MGVNKALIKQ AVKQILVAIG EDPEREGLRR TPDRVANMLE ELTNGREENV QYTLFEGSSN 

        70         80         90        100        110        120 
MVIVAGIRFS TLCEHHLLPM LGVTHVAYIP SDKVIGVSKI PRIVVKYSRM LQLQERLTRQ 

       130        140        150        160        170        180 
IMNEVSSATG SGDVMVLTEA YHTCMMIRGV RSASPLVSMA YKGKFNDSSL RLEFLEYIRP 


FRLNKFLT 

« Hide

References

[1]"Complete sequence of Caldivirga maquilingensis IC-167."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000852 Genomic DNA. Translation: ABW01366.1.
RefSeqYP_001540356.1. NC_009954.1.

3D structure databases

ProteinModelPortalA8MC60.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397948.Cmaq_0521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW01366; ABW01366; Cmaq_0521.
GeneID5709170.
KEGGcma:Cmaq_0521.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAQRIAEHM.

Enzyme and pathway databases

BioCycCMAQ397948:GH9M-533-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CALMQ
AccessionPrimary (citable) accession number: A8MC60
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways