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A8MBW0

- PSB1_CALMQ

UniProt

A8MBW0 - PSB1_CALMQ

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Protein

Proteasome subunit beta 1

Gene
psmB1, Cmaq_0458
Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-469-MONOMER.

Protein family/group databases

MEROPSiT01.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome beta subunit 1
Proteasome core protein PsmB 1
Gene namesi
Name:psmB1
Ordered Locus Names:Cmaq_0458
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
ProteomesiUP000001137: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1414Removed in mature form; by autocatalysis By similarityPRO_0000397282Add
BLAST
Chaini15 – 206192Proteasome subunit beta 1UniRule annotationPRO_0000397283Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN By similarity.

Protein-protein interaction databases

STRINGi397948.Cmaq_0458.

Structurei

3D structure databases

ProteinModelPortaliA8MBW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091083.
KOiK03433.
OMAiGYYIAHR.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A.
InterProiIPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MBW0-1 [UniParc]FASTAAdd to Basket

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MSRIHNDPKV LLTGTTTVGV VTKEGVVLAT DRRVTAGYYI AHRKGRKIWK    50
IDNHAAATMS GAVADVQMIL NELTHLAMNY RITHQAPVPI KTLANYASVV 100
MFYSRPMIYI AHMIIGGVDN EEGPVLYAVD WYGSFTREER FMSTGSGSPT 150
AFGVLEDGYR DDMSLDDAVK LATRAVRAAM LHDPGSGEGV DVITITKEAG 200
YREVQA 206
Length:206
Mass (Da):22,566
Last modified:December 4, 2007 - v1
Checksum:i58678DF039C364B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW01303.1.
RefSeqiYP_001540293.1. NC_009954.1.

Genome annotation databases

EnsemblBacteriaiABW01303; ABW01303; Cmaq_0458.
GeneIDi5709933.
KEGGicma:Cmaq_0458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW01303.1 .
RefSeqi YP_001540293.1. NC_009954.1.

3D structure databases

ProteinModelPortali A8MBW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 397948.Cmaq_0458.

Protein family/group databases

MEROPSi T01.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW01303 ; ABW01303 ; Cmaq_0458 .
GeneIDi 5709933.
KEGGi cma:Cmaq_0458.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091083.
KOi K03433.
OMAi GYYIAHR.

Enzyme and pathway databases

BioCyci CMAQ397948:GH9M-469-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_A. Proteasome_B_A.
InterProi IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Entry informationi

Entry nameiPSB1_CALMQ
AccessioniPrimary (citable) accession number: A8MBW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: December 4, 2007
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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