A8MAI6 (A8MAI6_CALMQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Cmaq_1740

Organism

Caldivirga maquilingensis (strain ATCC 700844 / DSMZ 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]

Taxonomic identifier

397948 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Caldivirga

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABW02563.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	212	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	265	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	123	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	125	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	133	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	250	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	222	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	234	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	292	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	331	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A8MAI6 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: BDBB5B9BDAE1F3E6	FASTA	347	38,661
	10 20 30 40 50 60 MYYRFPITRP RRLRSSRVIR NMVSETSLSP SNLVLPIFVK DEGSIEQINS MPGQYRYPIG 70 80 90 100 110 120 DELIKAINDA VESGVRAFLL FGVTKSKDPL GSLAYDKNGP VPKALRLLKE NFGDSIILMT 130 140 150 160 170 180 DVCLCDYTEH GHCGVVEYRD PVQVTQTTSQ PKYVVNNDAT ISIYAKIAVN YAEAGANVVA 190 200 210 220 230 240 PSGMMDGQVK AIREALDNNG FTDVIIMSYS SKYASTFYGP FREAADSAPR FGDRRSYQMD 250 260 270 280 290 300 PRNAYEALKE VSMDLEEGAD IVMVKPAMPY LDVIRLVKQH YPEVPLAAYQ VSGEYSMIKA 310 320 330 340 AALNGWLNEK MAVIESLIAI KRAGANIIIT YYAKEASRWI NEVESIL

References

[1]

"Complete sequence of Caldivirga maquilingensis IC-167." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700844 / DSMZ 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000852 Genomic DNA. Translation: ABW02563.1.
RefSeq	YP_001541553.1. NC_009954.1.
3D structure databases
ProteinModelPortal	A8MAI6.
ModBase	Search...
Protein-protein interaction databases
STRING	A8MAI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5708843.
GenomeReviews	Gene locus Cmaq_1740 in contig CP000852_GR.
KEGG	cma:Cmaq_1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8MAI6_CALMQ

Accession

Primary (citable) accession number: A8MAI6

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)