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A8MAC1 (MDH_CALMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:Cmaq_1675
OrganismCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]
Taxonomic identifier397948 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Malate dehydrogenase HAMAP-Rule MF_00487
PRO_1000081356

Regions

Nucleotide binding6 – 116NAD By similarity
Nucleotide binding116 – 1183NAD By similarity

Sites

Active site1731Proton acceptor By similarity
Binding site311NAD By similarity
Binding site801Substrate By similarity
Binding site861Substrate By similarity
Binding site931NAD By similarity
Binding site1181Substrate By similarity
Binding site1491Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MAC1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 166AF0CBC3C9A66D

FASTA30933,909
        10         20         30         40         50         60 
MITIVGSGRV GATTAAFLMF YELDNEVTLI DVIKGLPQGE ALDLNHAAAI LGKSVRYKGS 

        70         80         90        100        110        120 
NDYKDMEGSD IVIVTAGLAR KPGMTREELA GKNAEIISSI ADQIKKYAPN SIVIITTNPL 

       130        140        150        160        170        180 
DAMVYVLYKR LGFPRNRVIG FSGVLDSNRM AYYASQIIGI APESIIPVVL GQHGENMYPV 

       190        200        210        220        230        240 
PEASFVYGKP LTEFLTQEQY NDIVKKTIQA GADITNLRGF SSNWGPAAGL ALMVDSIKKN 

       250        260        270        280        290        300 
RRRVFEASVY LDGEYGVKDV FAEVPVVLGK NGVEKIIELN LTPEQRQKFM QSIEAVKKNL 


TQVPPQYLK 

« Hide

References

[1]"Complete sequence of Caldivirga maquilingensis IC-167."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000852 Genomic DNA. Translation: ABW02498.1.
RefSeqYP_001541488.1. NC_009954.1.

3D structure databases

ProteinModelPortalA8MAC1.
SMRA8MAC1. Positions 1-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397948.Cmaq_1675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW02498; ABW02498; Cmaq_1675.
GeneID5708826.
KEGGcma:Cmaq_1675.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAGANSYEA.
ProtClustDBPRK06223.

Enzyme and pathway databases

BioCycCMAQ397948:GH9M-1712-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_CALMQ
AccessionPrimary (citable) accession number: A8MAC1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families