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A8MAC1

- MDH_CALMQ

UniProt

A8MAC1 - MDH_CALMQ

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Protein

Malate dehydrogenase

Gene
mdh, Cmaq_1675
Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NAD By similarity
Binding sitei80 – 801Substrate By similarity
Binding sitei86 – 861Substrate By similarity
Binding sitei93 – 931NAD By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei149 – 1491Substrate By similarity
Active sitei173 – 1731Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NAD By similarity
Nucleotide bindingi116 – 1183NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Cmaq_1675
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
ProteomesiUP000001137: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Malate dehydrogenaseUniRule annotationPRO_1000081356Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397948.Cmaq_1675.

Structurei

3D structure databases

ProteinModelPortaliA8MAC1.
SMRiA8MAC1. Positions 1-307.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MAC1-1 [UniParc]FASTAAdd to Basket

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MITIVGSGRV GATTAAFLMF YELDNEVTLI DVIKGLPQGE ALDLNHAAAI    50
LGKSVRYKGS NDYKDMEGSD IVIVTAGLAR KPGMTREELA GKNAEIISSI 100
ADQIKKYAPN SIVIITTNPL DAMVYVLYKR LGFPRNRVIG FSGVLDSNRM 150
AYYASQIIGI APESIIPVVL GQHGENMYPV PEASFVYGKP LTEFLTQEQY 200
NDIVKKTIQA GADITNLRGF SSNWGPAAGL ALMVDSIKKN RRRVFEASVY 250
LDGEYGVKDV FAEVPVVLGK NGVEKIIELN LTPEQRQKFM QSIEAVKKNL 300
TQVPPQYLK 309
Length:309
Mass (Da):33,909
Last modified:December 4, 2007 - v1
Checksum:i166AF0CBC3C9A66D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW02498.1.
RefSeqiYP_001541488.1. NC_009954.1.

Genome annotation databases

EnsemblBacteriaiABW02498; ABW02498; Cmaq_1675.
GeneIDi5708826.
KEGGicma:Cmaq_1675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000852 Genomic DNA. Translation: ABW02498.1 .
RefSeqi YP_001541488.1. NC_009954.1.

3D structure databases

ProteinModelPortali A8MAC1.
SMRi A8MAC1. Positions 1-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 397948.Cmaq_1675.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW02498 ; ABW02498 ; Cmaq_1675 .
GeneIDi 5708826.
KEGGi cma:Cmaq_1675.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.

Enzyme and pathway databases

BioCyci CMAQ397948:GH9M-1712-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Entry informationi

Entry nameiMDH_CALMQ
AccessioniPrimary (citable) accession number: A8MAC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi