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A8MAC1

- MDH_CALMQ

UniProt

A8MAC1 - MDH_CALMQ

Protein

Malate dehydrogenase

Gene

mdh

Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADUniRule annotation
    Binding sitei80 – 801SubstrateUniRule annotation
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei93 – 931NADUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation
    Active sitei173 – 1731Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 116NADUniRule annotation
    Nucleotide bindingi116 – 1183NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCMAQ397948:GH9M-1712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Cmaq_1675
    OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
    Taxonomic identifieri397948 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
    ProteomesiUP000001137: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Malate dehydrogenasePRO_1000081356Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi397948.Cmaq_1675.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MAC1.
    SMRiA8MAC1. Positions 1-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYAPSAFV.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8MAC1-1 [UniParc]FASTAAdd to Basket

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    MITIVGSGRV GATTAAFLMF YELDNEVTLI DVIKGLPQGE ALDLNHAAAI    50
    LGKSVRYKGS NDYKDMEGSD IVIVTAGLAR KPGMTREELA GKNAEIISSI 100
    ADQIKKYAPN SIVIITTNPL DAMVYVLYKR LGFPRNRVIG FSGVLDSNRM 150
    AYYASQIIGI APESIIPVVL GQHGENMYPV PEASFVYGKP LTEFLTQEQY 200
    NDIVKKTIQA GADITNLRGF SSNWGPAAGL ALMVDSIKKN RRRVFEASVY 250
    LDGEYGVKDV FAEVPVVLGK NGVEKIIELN LTPEQRQKFM QSIEAVKKNL 300
    TQVPPQYLK 309
    Length:309
    Mass (Da):33,909
    Last modified:December 4, 2007 - v1
    Checksum:i166AF0CBC3C9A66D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000852 Genomic DNA. Translation: ABW02498.1.
    RefSeqiYP_001541488.1. NC_009954.1.

    Genome annotation databases

    EnsemblBacteriaiABW02498; ABW02498; Cmaq_1675.
    GeneIDi5708826.
    KEGGicma:Cmaq_1675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000852 Genomic DNA. Translation: ABW02498.1 .
    RefSeqi YP_001541488.1. NC_009954.1.

    3D structure databases

    ProteinModelPortali A8MAC1.
    SMRi A8MAC1. Positions 1-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 397948.Cmaq_1675.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW02498 ; ABW02498 ; Cmaq_1675 .
    GeneIDi 5708826.
    KEGGi cma:Cmaq_1675.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YAPSAFV.

    Enzyme and pathway databases

    BioCyci CMAQ397948:GH9M-1712-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

    Entry informationi

    Entry nameiMDH_CALMQ
    AccessioniPrimary (citable) accession number: A8MAC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3