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Protein

Malate dehydrogenase

Gene

mdh

Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADUniRule annotation
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei93 – 931NADUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NADUniRule annotation
Nucleotide bindingi116 – 1183NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cmaq_1675
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
ProteomesiUP000001137 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Malate dehydrogenasePRO_1000081356Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397948.Cmaq_1675.

Structurei

3D structure databases

ProteinModelPortaliA8MAC1.
SMRiA8MAC1. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiNDYKDME.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MAC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITIVGSGRV GATTAAFLMF YELDNEVTLI DVIKGLPQGE ALDLNHAAAI
60 70 80 90 100
LGKSVRYKGS NDYKDMEGSD IVIVTAGLAR KPGMTREELA GKNAEIISSI
110 120 130 140 150
ADQIKKYAPN SIVIITTNPL DAMVYVLYKR LGFPRNRVIG FSGVLDSNRM
160 170 180 190 200
AYYASQIIGI APESIIPVVL GQHGENMYPV PEASFVYGKP LTEFLTQEQY
210 220 230 240 250
NDIVKKTIQA GADITNLRGF SSNWGPAAGL ALMVDSIKKN RRRVFEASVY
260 270 280 290 300
LDGEYGVKDV FAEVPVVLGK NGVEKIIELN LTPEQRQKFM QSIEAVKKNL

TQVPPQYLK
Length:309
Mass (Da):33,909
Last modified:December 4, 2007 - v1
Checksum:i166AF0CBC3C9A66D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000852 Genomic DNA. Translation: ABW02498.1.
RefSeqiWP_012186717.1. NC_009954.1.
YP_001541488.1. NC_009954.1.

Genome annotation databases

EnsemblBacteriaiABW02498; ABW02498; Cmaq_1675.
GeneIDi5708826.
KEGGicma:Cmaq_1675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000852 Genomic DNA. Translation: ABW02498.1.
RefSeqiWP_012186717.1. NC_009954.1.
YP_001541488.1. NC_009954.1.

3D structure databases

ProteinModelPortaliA8MAC1.
SMRiA8MAC1. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi397948.Cmaq_1675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW02498; ABW02498; Cmaq_1675.
GeneIDi5708826.
KEGGicma:Cmaq_1675.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiNDYKDME.

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1712-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Entry informationi

Entry nameiMDH_CALMQ
AccessioniPrimary (citable) accession number: A8MAC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 27, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.