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A8M9D7 (SYE_CALMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase
Short name=GluRS
Gene names
Name:gltX
Ordered Locus Names:Cmaq_1533
OrganismCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) [Complete proteome] [HAMAP]
Taxonomic identifier397948 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Glutamate--tRNA ligase HAMAP-Rule MF_00022
PRO_0000367798

Regions

Motif112 – 12211"HIGH" region HAMAP-Rule MF_00022

Sequences

Sequence LengthMass (Da)Tools
A8M9D7 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 7FFD62F0614722B7

FASTA58866,452
        10         20         30         40         50         60 
MENAVRDLAL KHALINAVKF NGKADVKAVV SKIFADNPEL RGNAKQVVEV VKEVVNYVNS 

        70         80         90        100        110        120 
LTLDEQRRIL EEKWPEALGA RRTVEEKRGD IESLPELPDA DKLSKLTFRF APNPDFYLHL 

       130        140        150        160        170        180 
GSARPAIVNY AYKLKYANKG KDSRFILRFE DTDPRIKRPL LDAYDAIRED LRWLGVKWDE 

       190        200        210        220        230        240 
EYIQSDRMSI YYEYARKLIE NGGAYVVAKG SGCEPDDWKR LKIEGKPCLT REAESSRNLE 

       250        260        270        280        290        300 
LFDKMLEGAF NEGEAIVAVK TDLSSPDPSI RDWVAFRVID AHKYPHPRVG DKYIVWPTYN 

       310        320        330        340        350        360 
FAVAIDDHLM GITHVLRAQE HRVNTVKQYY VFKAFGWEQP YTIHFGRLKI EGLKLSKSIL 

       370        380        390        400        410        420 
KKLNLTKDDV TLPTLAGLRN RGITPEAIWS LILFVGIKET DATISLKNLY AYNRRVIEPL 

       430        440        450        460        470        480 
ANRYMFVKNP VKLRLRGVGD LIEAKIPMHP SYPERGIRVI KITGEGGYAN VYVQASDVKP 

       490        500        510        520        530        540 
GLVVRLMGLG NVKVINVSGN EAEADFIGQS VEDARRSEAP IVQWAPPDAV NAEVIIPVNV 

       550        560        570        580 
GQVTVDNGLA EPAVAKLEQG TVMQFIRYGF VKLMGSSNGK LRLVYIHD 

« Hide

References

[1]"Complete sequence of Caldivirga maquilingensis IC-167."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ivanova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000852 Genomic DNA. Translation: ABW02356.1.
RefSeqYP_001541346.1. NC_009954.1.

3D structure databases

ProteinModelPortalA8M9D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397948.Cmaq_1533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW02356; ABW02356; Cmaq_1533.
GeneID5709095.
KEGGcma:Cmaq_1533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000073585.
KOK01885.
OMAYLGWDDP.

Enzyme and pathway databases

BioCycCMAQ397948:GH9M-1570-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_A. Glu_tRNA_synth_A.
InterProIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00463. gltX_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYE_CALMQ
AccessionPrimary (citable) accession number: A8M9D7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries