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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Cmaq_1533
OrganismiCaldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Taxonomic identifieri397948 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeCaldivirga
ProteomesiUP000001137 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Glutamate--tRNA ligasePRO_0000367798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397948.Cmaq_1533.

Structurei

3D structure databases

ProteinModelPortaliA8M9D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 12211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiGEYSGWD.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A8M9D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENAVRDLAL KHALINAVKF NGKADVKAVV SKIFADNPEL RGNAKQVVEV
60 70 80 90 100
VKEVVNYVNS LTLDEQRRIL EEKWPEALGA RRTVEEKRGD IESLPELPDA
110 120 130 140 150
DKLSKLTFRF APNPDFYLHL GSARPAIVNY AYKLKYANKG KDSRFILRFE
160 170 180 190 200
DTDPRIKRPL LDAYDAIRED LRWLGVKWDE EYIQSDRMSI YYEYARKLIE
210 220 230 240 250
NGGAYVVAKG SGCEPDDWKR LKIEGKPCLT REAESSRNLE LFDKMLEGAF
260 270 280 290 300
NEGEAIVAVK TDLSSPDPSI RDWVAFRVID AHKYPHPRVG DKYIVWPTYN
310 320 330 340 350
FAVAIDDHLM GITHVLRAQE HRVNTVKQYY VFKAFGWEQP YTIHFGRLKI
360 370 380 390 400
EGLKLSKSIL KKLNLTKDDV TLPTLAGLRN RGITPEAIWS LILFVGIKET
410 420 430 440 450
DATISLKNLY AYNRRVIEPL ANRYMFVKNP VKLRLRGVGD LIEAKIPMHP
460 470 480 490 500
SYPERGIRVI KITGEGGYAN VYVQASDVKP GLVVRLMGLG NVKVINVSGN
510 520 530 540 550
EAEADFIGQS VEDARRSEAP IVQWAPPDAV NAEVIIPVNV GQVTVDNGLA
560 570 580
EPAVAKLEQG TVMQFIRYGF VKLMGSSNGK LRLVYIHD
Length:588
Mass (Da):66,452
Last modified:December 4, 2007 - v1
Checksum:i7FFD62F0614722B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000852 Genomic DNA. Translation: ABW02356.1.
RefSeqiWP_012186575.1. NC_009954.1.
YP_001541346.1. NC_009954.1.

Genome annotation databases

EnsemblBacteriaiABW02356; ABW02356; Cmaq_1533.
GeneIDi5709095.
KEGGicma:Cmaq_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000852 Genomic DNA. Translation: ABW02356.1.
RefSeqiWP_012186575.1. NC_009954.1.
YP_001541346.1. NC_009954.1.

3D structure databases

ProteinModelPortaliA8M9D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi397948.Cmaq_1533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW02356; ABW02356; Cmaq_1533.
GeneIDi5709095.
KEGGicma:Cmaq_1533.

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiGEYSGWD.

Enzyme and pathway databases

BioCyciCMAQ397948:GH9M-1570-MONOMER.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700844 / DSM 13496 / JCM 10307 / IC-167.

Entry informationi

Entry nameiSYE_CALMQ
AccessioniPrimary (citable) accession number: A8M9D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.