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A8M8F3

- PANC_SALAI

UniProt

A8M8F3 - PANC_SALAI

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Protein
Pantothenate synthetase
Gene
panC, Sare_4718
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donor By similarity
Binding sitei59 – 591Beta-alanine By similarity
Binding sitei59 – 591Pantoate By similarity
Binding sitei152 – 1521Pantoate By similarity
Binding sitei175 – 1751ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358ATP By similarity
Nucleotide bindingi146 – 1494ATP By similarity
Nucleotide bindingi183 – 1864ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-4774-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Sare_4718
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Pantothenate synthetaseUniRule annotation
PRO_1000076864Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_4718.

Structurei

3D structure databases

ProteinModelPortaliA8M8F3.
SMRiA8M8F3. Positions 3-281.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiEIDYVEV.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A8M8F3-1 [UniParc]FASTAAdd to Basket

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MTELVHTRAE LAAARDGLTG TVGVVMTMGA LHSGHETLLR AARERADHVL    50
VTIFVNPLQF GPDEDFNRYP RTLDVDLEIC RRAGVAVVFA PVVTELYPEG 100
KPRVWVAPGQ LGEELEGQSR PGFFHGVLTV VLKLLHVTRP DLAFFGEKDY 150
QQLTLVRRMV GDLDVPVEIV GVPTVREPDG LALSSRNRYL SPDERAAALS 200
LSGALRAGAA AAAVGADAGA VLAAAHAAFE SGPSGARLDY LVLTDSDLEP 250
GPTAGPARML VAAWVGTTRL IDNMSVQLAP YS 282
Length:282
Mass (Da):30,023
Last modified:December 4, 2007 - v1
Checksum:iDE5C2C5007F24724
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABW00472.1.
RefSeqiYP_001539462.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABW00472; ABW00472; Sare_4718.
GeneIDi5706020.
KEGGisaq:Sare_4718.
PATRICi23438056. VBISalAre38676_4769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABW00472.1 .
RefSeqi YP_001539462.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8M8F3.
SMRi A8M8F3. Positions 3-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_4718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW00472 ; ABW00472 ; Sare_4718 .
GeneIDi 5706020.
KEGGi saq:Sare_4718.
PATRICi 23438056. VBISalAre38676_4769.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi EIDYVEV.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci SARE391037:GH66-4774-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiPANC_SALAI
AccessioniPrimary (citable) accession number: A8M8F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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