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A8M811 (A8M811_SALAI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Sare_1446
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV97345.1
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116

Cofactor

Magnesium By similarity. HAMAP MF_00116

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region65 – 673Substrate binding By similarity HAMAP MF_00116
Region82 – 843Substrate binding By similarity HAMAP MF_00116

Sites

Binding site781Substrate By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
A8M811 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 10175C0BE6368196

FASTA16716,943
        10         20         30         40         50         60 
MTDVPVPVRQ LDPGLPLPAY AHPGDAGADL VAAADVELPP GGRALVPTGV AIALPEGYVG 

        70         80         90        100        110        120 
LVHPRSGLAA RLGVTVLNAP GTVDAGYRGE ILVNLINHDR ETSARIARGD RIAQLVVQRV 

       130        140        150        160 
ARARFQPTTE LPASQRGAGG HGSTGGHAGL VSAPTGTDGR QPVPEAS

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV97345.1.
RefSeqYP_001536336.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8M811.
SMRA8M811. Positions 8-120.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8M811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5703353.
GenomeReviewsGene locus Sare_1446 in contig CP000850_GR.
KEGGsaq:Sare_1446.
PATRIC23431392. VBISalAre38676_1472.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG436079.
OMAKIAQMVI.
ProtClustDBCLSK969027.

Enzyme and pathway databases

BioCycSARE391037:SARE_1446-MONOMER.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8M811_SALAI
AccessionPrimary (citable) accession number: A8M811
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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