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A8M758

- PNP_SALAI

UniProt

A8M758 - PNP_SALAI

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Sare_1339
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi516 – 5161Magnesium By similarity
Metal bindingi522 – 5221Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-1362-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Sare_1339
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329827Add
BLAST

Proteomic databases

PRIDEiA8M758.

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_1339.

Structurei

3D structure databases

ProteinModelPortaliA8M758.
SMRiA8M758. Positions 13-716.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini582 – 64160KH
Add
BLAST
Domaini653 – 72270S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8M758-1 [UniParc]FASTAAdd to Basket

« Hide

MTESNLGAQS RTATIDNGAF GTRVITFSTG RLARQAAGSV VAQLGETVVL    50
SATTVGRQPK EQFDFFPLTV DVEERMYAAG RIPGSFFRRE GRPSEDAILT 100
CRLIDRPLRP SFVKGLRNEV QVVETVLALD PSHPYDVVAI NAASMSTKLS 150
GLPFSGPIGA TRMAHIDGSW VAFPTHEELE RATFDMVVAG RALPDGDVAI 200
MMVEAEATEH TVKLVAGGAS APTEEVVASG LEAAKPAIRE LCRAQSELAE 250
VAAKPVAEFP VFLDYSDDAY QAVADLARSD VAEALKIAGK ADREEALDRI 300
KARVIEDLGP RFEGREKELS AALRSLTKSE VRSRVLREQV RIDGRGPRDI 350
RPLTAEVGVL PRVHGSALFE RGETQILGVT TLNMLRMEQS LDTLSPEKSK 400
RYMHNYNFPP YSTGETGRVG SPKRREIGHG ALAERALIPV LPSREEFPYA 450
IRQVSEALGS NGSTSMGSVC ASTLGLLSAG VPLKAPVAGI AMGLISDEVE 500
GKTRYVTLTD ILGAEDAFGD MDFKVAGTQE FVTALQLDTK LDGIPSDVLA 550
AALQQAYEAR QTILEVMQAA IEAPATMSDY APRVTTVKIP VDKIGMVIGP 600
KGQTINAIQD ETGAEISIED DGTIYVGATN GPSAQAAVER VNAIANPTLP 650
KVGDRFLGTV VKTAAFGAFV SLLPGRDGLL HISKVGDGKR VEKVEDYLNV 700
GDKVEVEIAD IDQRGKIYLD KVRPEGAEGP AEAAATDRPA GRDRGDRAPR 750
DRGDRGDRER GSRGPDRGDG GEGGGESRPR RRTRHS 786
Length:786
Mass (Da):84,170
Last modified:December 4, 2007 - v1
Checksum:iCC4559631305B7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV97240.1.
RefSeqiYP_001536231.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV97240; ABV97240; Sare_1339.
GeneIDi5703870.
KEGGisaq:Sare_1339.
PATRICi23431170. VBISalAre38676_1361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV97240.1 .
RefSeqi YP_001536231.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8M758.
SMRi A8M758. Positions 13-716.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_1339.

Proteomic databases

PRIDEi A8M758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV97240 ; ABV97240 ; Sare_1339 .
GeneIDi 5703870.
KEGGi saq:Sare_1339.
PATRICi 23431170. VBISalAre38676_1361.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SARE391037:GH66-1362-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiPNP_SALAI
AccessioniPrimary (citable) accession number: A8M758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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