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A8M721 (A8M721_SALAI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Sare_1302
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV97203.1
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 3930NADP By similarity HAMAP MF_00183

Sites

Metal binding1621Divalent metal cation By similarity HAMAP MF_00183
Metal binding1641Divalent metal cation By similarity HAMAP MF_00183
Metal binding2331Divalent metal cation By similarity HAMAP MF_00183
Binding site1381Substrate By similarity HAMAP MF_00183
Binding site1641Substrate By similarity HAMAP MF_00183
Binding site1881Substrate By similarity HAMAP MF_00183
Binding site2111Substrate By similarity HAMAP MF_00183
Binding site2331Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A8M721 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 336AC227A1136282

FASTA40342,236
        10         20         30         40         50         60 
MTSPRDLVLL GSTGSIGTQA IDVARRNPDR FRVVALGAGG GNVGLLAAQA LDLGVEAVGV 

        70         80         90        100        110        120 
ARASVVQDLQ LAFYAEASRR GWARGDVKLP KIIAGPDAMT ELAQWPGDVV LNGVVGSLGL 

       130        140        150        160        170        180 
APTLAALRAG RTLALANKES LVAGGPLVRA AMTRPEQIVP VDSEHTALAQ CLRSGCRPEV 

       190        200        210        220        230        240 
RRLIVTASGG PFRGWRRDEL THVTPEQALA HPTWDMGPVI TINSATMVNK ALEVIEAHEL 

       250        260        270        280        290        300 
FGVPYADIAV TVHPQSVIHS MVEFVDGSTI AQASPPDMRL PIAVALGWPD RVPDAAPAVD 

       310        320        330        340        350        360 
WTTSHTWQFA PLDDAAFPAV ALAKAAGEAG RSRPAIYNAA NEECVAAFVA GRLPFLGIVD 

       370        380        390        400 
TLEQVLADAP DFGEPGTVED VLAAESWARG HAQTIIEKSV EGA

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV97203.1.
RefSeqYP_001536194.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8M721.
SMRA8M721. Positions 4-397.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8M721.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5703682.
GenomeReviewsGene locus Sare_1302 in contig CP000850_GR.
KEGGsaq:Sare_1302.
PATRIC23431094. VBISalAre38676_1323.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycSARE391037:SARE_1302-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8M721_SALAI
AccessionPrimary (citable) accession number: A8M721
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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