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A8M6W7

- ACDH2_SALAI

UniProt

A8M6W7 - ACDH2_SALAI

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Protein
Acetaldehyde dehydrogenase 2
Gene
Sare_4566
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei275 – 2751NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 204NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSARE391037:GH66-4622-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:Sare_4566
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387737Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_4566.

Structurei

3D structure databases

ProteinModelPortaliA8M6W7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiCVPALNL.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A8M6W7-1 [UniParc]FASTAAdd to Basket

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MSTQTHPAPL RTAIVGTGNI GTDLLLKVEA SPLLTCVLFA GRRAESPGIE    50
LARGRGVATS TGGIDAVVDA ADDIDLVFDA TSARDAVRHW AVIKPLGLPF 100
IDLTPANQGK FCVPALNLED CLDEQYLSMV TCGGQAAVPM ARCITQIAGH 150
VDYLEIVSAS ASASVGPASR ANLDEYVHTT EQATAEFCST ARTKTVLIIN 200
PADPGIVMRN SIAVSTTERI DIDALRDSVT AMEKEIHSYV PGYRIVVPPV 250
ATGDCYLLTV EVEGLGDYFP RSAGNLDIIT CAAVAAAEAR SGLRR 295
Length:295
Mass (Da):31,069
Last modified:December 4, 2007 - v1
Checksum:i4BDADD6E374F4918
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABW00335.1.
RefSeqiWP_012184561.1. NC_009953.1.
YP_001539325.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABW00335; ABW00335; Sare_4566.
GeneIDi5705424.
KEGGisaq:Sare_4566.
PATRICi23437744. VBISalAre38676_4614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABW00335.1 .
RefSeqi WP_012184561.1. NC_009953.1.
YP_001539325.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8M6W7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_4566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW00335 ; ABW00335 ; Sare_4566 .
GeneIDi 5705424.
KEGGi saq:Sare_4566.
PATRICi 23437744. VBISalAre38676_4614.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi CVPALNL.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SARE391037:GH66-4622-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiACDH2_SALAI
AccessioniPrimary (citable) accession number: A8M6W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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