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Protein

Ribonuclease HII

Gene

rnhB

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Divalent metal cationUniRule annotation1
Metal bindingi35Divalent metal cationUniRule annotation1
Metal bindingi128Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-1224-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:Sare_1201
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003349521 – 269Ribonuclease HIIAdd BLAST269

Proteomic databases

PRIDEiA8M684

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_1201

Structurei

3D structure databases

ProteinModelPortaliA8M684
SMRiA8M684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2 Bacteria
COG0164 LUCA
HOGENOMiHOG000100288
KOiK03470
OMAiNILHASM
OrthoDBiPOG091H011N

Family and domain databases

CDDicd07182 RNase_HII_bacteria_HII_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00052_B RNase_HII_B, 1 hit
InterProiView protein in InterPro
IPR022898 RNase_HII
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PTHR10954:SF18 PTHR10954:SF18, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

A8M684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTPPRTVVR RDGGLYALER ALQRRGFRHV AGADEAGRGA CAGPLVAAAA
60 70 80 90 100
VLPEGRRGEI DGLADSKLLT PASRERVYAE VVARALAYAV VVIPAAEVDL
110 120 130 140 150
RGLHVCNLAA MRRALASLAT APEYVLTDGF GVDGLDVPGL AVWKGDRVAA
160 170 180 190 200
CVAAASVLAK VTRDRIMVEL DTTFPGYGFA EHKGYITAEH SAALRERGPC
210 220 230 240 250
PEHRFSYVNV ATVSGRRGAP PRARRPLVVG LDEPMERSGA VEGTVGVALG
260
ERPWAAVSVG NDVAMEGGM
Length:269
Mass (Da):28,286
Last modified:December 4, 2007 - v1
Checksum:i89F12F495C34116C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV97109.1
RefSeqiWP_012181418.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV97109; ABV97109; Sare_1201
GeneIDi5703985
KEGGisaq:Sare_1201
PATRICifig|391037.6.peg.1220

Similar proteinsi

Entry informationi

Entry nameiRNH2_SALAI
AccessioniPrimary (citable) accession number: A8M684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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