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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-2734-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Sare_2704
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000835941 – 380Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_2704

Structurei

3D structure databases

ProteinModelPortaliA8M4X3
SMRiA8M4X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A8M4X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYDLPPLRE PDLPRTAKVR PVALRTGWTT GACATAAAKA ALTALVTGVA
60 70 80 90 100
PAEVEIGLPA GRRVRFPVAR CDRRDEGAEA VVVKDAGDDP DVTHGAELTA
110 120 130 140 150
TVGWRPVPGL ALEGGPGVGT VTKPGLGLAV GGPAINDTPR RMIGEAVAEV
160 170 180 190 200
VDLTAVGVRV VISVPRGEIM ARKTTNRRLG IVGGISILGT TGIVRPFSTA
210 220 230 240 250
SWRASVVQAV QVAAAQGERT VVLCTGGRTE RGARALLPEL PEVCFVEVGD
260 270 280 290 300
FTGAAVTAAV THGLSGVAFV GMAGKLAKLA AGVLMTHYTR SKVDLSLLGA
310 320 330 340 350
VTAEAGGTAD LATAVTAANT GRHAYELWEA AGLLGPAGDL LCSRVRAVLR
360 370 380
RFAGDAVAVD VAMVDFTGAR VVASSGRWAR
Length:380
Mass (Da):38,769
Last modified:December 4, 2007 - v1
Checksum:iD42A71C3178679AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV98541.1
RefSeqiWP_012182842.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV98541; ABV98541; Sare_2704
GeneIDi5707724
KEGGisaq:Sare_2704
PATRICifig|391037.6.peg.2740

Similar proteinsi

Entry informationi

Entry nameiCBID_SALAI
AccessioniPrimary (citable) accession number: A8M4X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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