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Protein

Urocanate hydratase

Gene

hutU

Organism
Salinispora arenicola (strain CNS-205)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.UniRule annotation

Catalytic activityi

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotationSAAS annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (Sare_0996)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124NADUniRule annotation1
Binding sitei190NADUniRule annotation1
Binding sitei195NADUniRule annotation1
Binding sitei315NAD; via carbonyl oxygenUniRule annotation1
Active sitei403UniRule annotation1
Binding sitei485NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 47NADUniRule annotation2
Nucleotide bindingi170 – 172NADUniRule annotation3
Nucleotide bindingi236 – 237NADUniRule annotation2
Nucleotide bindingi257 – 261NADUniRule annotation5
Nucleotide bindingi266 – 267NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processHistidine metabolismUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-1020-MONOMER
UniPathwayiUPA00379; UER00550

Names & Taxonomyi

Protein namesi
Recommended name:
Urocanate hydrataseUniRule annotationSAAS annotation (EC:4.2.1.49UniRule annotationSAAS annotation)
Short name:
UrocanaseUniRule annotation
Alternative name(s):
Imidazolonepropionate hydrolaseUniRule annotation
Gene namesi
Name:hutUUniRule annotation
Ordered Locus Names:Sare_1000Imported
OrganismiSalinispora arenicola (strain CNS-205)Imported
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_1000

Structurei

3D structure databases

ProteinModelPortaliA8M4I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 131Urocanase_NInterPro annotationAdd BLAST127
Domaini134 – 341UrocanaseInterPro annotationAdd BLAST208
Domaini344 – 538Urocanase_CInterPro annotationAdd BLAST195

Sequence similaritiesi

Belongs to the urocanase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CGP Bacteria
COG2987 LUCA
HOGENOMiHOG000237606
KOiK01712
OMAiVSFHHGG
OrthoDBiPOG091H0CXO

Family and domain databases

Gene3Di3.40.50.10730, 1 hit
HAMAPiMF_00577 HutU, 1 hit
InterProiView protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf
PANTHERiPTHR12216 PTHR12216, 1 hit
PfamiView protein in Pfam
PF01175 Urocanase, 1 hit
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit
PIRSFiPIRSF001423 Urocanate_hydrat, 1 hit
SUPFAMiSSF111326 SSF111326, 1 hit
TIGRFAMsiTIGR01228 hutU, 1 hit
PROSITEiView protein in PROSITE
PS01233 UROCANASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8M4I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQPIRATRG TTRTAQGWPQ EAARRMLMNN LDPEVAERPE DLVVYGGTGK
60 70 80 90 100
AARDWPSYRA LLDTLTDLRD DETMLVQSGR PVAVMRTHEW APRVLLANSN
110 120 130 140 150
LVGDWATWPE FRRLEQLGLT MYGQMTAGSW IYIGTQGILQ GTYETFAAVA
160 170 180 190 200
AKRFGGSLAG TLTLTAGCGG MGGAQPLAVT MNGGSCLIVD VDRSRLERRV
210 220 230 240 250
REHYLDEVAD SLDDAVQRAL AARDQRRARS VGVVGNAATI FPELLRRGVP
260 270 280 290 300
VDVVTDQTSA HDPLSYLPEG VELTDARDYA AAKPAEFTDR ARASMARHVE
310 320 330 340 350
AMVGFLDAGA EVFDYGNSIR GEAQLGGYSR AFDFPGFVPA YIRPLFCAGK
360 370 380 390 400
GPFRWAALSG DPADIAATDR AILDLFPENE PLARWIRMAG ERVAFQGLPA
410 420 430 440 450
RICWLGYGER DRAGVRFNEM VAAGELSAPV VIGRDHLDCG SVASPYRETE
460 470 480 490 500
AMADGSDAIA DWPLLNALVN TASGASWVSI HHGGGVGIGR SIHAGQVCVA
510 520 530 540
DGSALAGQKI ERVLTNDPAM GVVRHVDAGY DEARQVAERT GLHIPMTAA
Length:549
Mass (Da):59,139
Last modified:December 4, 2007 - v1
Checksum:i2D011233090C1C13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV96911.1
RefSeqiWP_012181221.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV96911; ABV96911; Sare_1000
GeneIDi5704682
KEGGisaq:Sare_1000
PATRICifig|391037.6.peg.1016

Similar proteinsi

Entry informationi

Entry nameiA8M4I7_SALAI
AccessioniPrimary (citable) accession number: A8M4I7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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