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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-876-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Sare_0861
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001454291 – 220Peptide methionine sulfoxide reductase MsrAAdd BLAST220

Proteomic databases

PRIDEiA8M3K6

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_0861

Structurei

3D structure databases

ProteinModelPortaliA8M3K6
SMRiA8M3K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP Bacteria
COG0225 LUCA
HOGENOMiHOG000263862
KOiK07304
OMAiMRQGGDI
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A8M3K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLRRMKAEL INPEQALPGR PIAMPVADRH EVLGTPLAGP FPEGTQVAVF
60 70 80 90 100
GMGCFWGAER LFWTLPGVLT TSVGYAGGYT PNPSYEEVCS GRTGHAEVVQ
110 120 130 140 150
VRYDPTKIAY EDLLKVFWEN HDPTQGMRQG NDVGTQYRSA IYTTTEEQLT
160 170 180 190 200
AAQASRDAFA PVVARAGKGE ITTEIGPLGD YYFAEDYHQQ YLAPTKNPGG
210 220
YCNHGPNGLS CPVGVARTTG
Length:220
Mass (Da):23,936
Last modified:December 4, 2007 - v1
Checksum:iCEB9BC4C6CA974A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV96779.1
RefSeqiWP_012181089.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV96779; ABV96779; Sare_0861
GeneIDi5705126
KEGGisaq:Sare_0861
PATRICifig|391037.6.peg.878

Similar proteinsi

Entry informationi

Entry nameiMSRA_SALAI
AccessioniPrimary (citable) accession number: A8M3K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health