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A8M2X4 (A8M2X4_SALAI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Sare_0824
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV96742.1
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A8M2X4 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 5AA27713E1ADF635

FASTA32835,653
        10         20         30         40         50         60 
MSEAEATRTG SKRVLLAKPR GYCAGVDRAV QTVEEALKLY GAPIYVRKQI VHNRHVVRTL 

        70         80         90        100        110        120 
EAKGAIFVEE NEEVPEGATV VFSAHGVAPE VHEQARARSL KSIDATCPLV TKVHQEAKRF 

       130        140        150        160        170        180 
AAQDYDILLI GHEGHEEVVG TSGEAPEHIQ LVDGPEDADQ VTVRDPDKVV WLSQTTLSVD 

       190        200        210        220        230        240 
ETLETVARLK KRLPLLQSPP SDDICYATSN RQHVVKQIAP DCDVMIVVGS TNSSNSVRLV 

       250        260        270        280        290        300 
EVALDAGARA GHLVDFAREI DDAWLDGART VGLTSGASVP EELVQEVLAH LAARGFTDVE 

       310        320 
EVVTADERLT FSLPQELKRD MRAAVAHG

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV96742.1.
RefSeqYP_001535733.1. NC_009953.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8M2X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5704128.
GenomeReviewsGene locus Sare_0824 in contig CP000850_GR.
KEGGsaq:Sare_0824.
PATRIC23430111. VBISalAre38676_0841.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAAMAPECD.
ProtClustDBPRK01045.

Enzyme and pathway databases

BioCycSARE391037:SARE_0824-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8M2X4_SALAI
AccessionPrimary (citable) accession number: A8M2X4
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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