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A8M2V8

- PCKG_SALAI

UniProt

A8M2V8 - PCKG_SALAI

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, Sare_0807
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei223 – 2231Substrate; via amide nitrogen By similarity
Metal bindingi230 – 2301Manganese By similarity
Binding sitei230 – 2301Substrate By similarity
Metal bindingi250 – 2501Manganese; via tele nitrogen By similarity
Binding sitei272 – 2721Substrate By similarity
Active sitei274 – 2741 By similarity
Metal bindingi297 – 2971Manganese By similarity
Binding sitei389 – 3891GTP By similarity
Binding sitei420 – 4201GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi273 – 2786GTP By similarity
Nucleotide bindingi517 – 5204GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-820-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:Sare_0807
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_1000080988Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_0807.

Structurei

3D structure databases

ProteinModelPortaliA8M2V8.
SMRiA8M2V8. Positions 13-608.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni387 – 3893Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8M2V8-1 [UniParc]FASTAAdd to Basket

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MVAPATVRGI DQAPTSHPKL LAWVREIAEL TTPDRVVWAD GSDEEWRRLT    50
DELVEAGTLI RLNPEKKPNS FYARTDPTDV ARVEERTYIC SVDEADAGPT 100
NNWMAPAEMK RTMTELYRGC MRGRTMYVIP FCMGPVEAEQ PMFGVEITDS 150
PYVVASMRIM TRMGAKILEA MGDDADFVHA LHSIGAPLAP GQQDVSWPCN 200
ETKYISHFPE TREIWSYGSG YGGNSLLGKK CYSLRIASVM GRDEGWLAEH 250
MLILKITSPE GRVYHIAGAF PSACGKTNLA MLEPTIPGWK VETIGDDIAW 300
MRFGPDGRLY AVNPEYGLFG VAPGTDWKTN ANAMRTLDRG NSIFTNVALT 350
DDGDIWWEGM GEPPAHLVDW KGNDWTPESD DLSSHANSRF CTPITQCPIL 400
AEDYYDPNGV PIDAILFGGR RRDTIPLVTE ARDWVHGVYL GATLSSETTA 450
AASGAVGVVR RDPMAMLPFI GYNAGDYFRH WIEMGKGTDG DESKLPRVYY 500
VNWFRKDAEG SFLWPGFGEN SRVLKWIVER IEGRADAVET PIGMVPAADA 550
LDVEGLDMTS EDIRIALKVD VNEWRDELPL VTEWFEKFGD KLPGVLWAEL 600
DALRARLDAE AQ 612
Length:612
Mass (Da):68,136
Last modified:December 4, 2007 - v1
Checksum:i1086C810E31E146D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV96726.1.
RefSeqiYP_001535717.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV96726; ABV96726; Sare_0807.
GeneIDi5705201.
KEGGisaq:Sare_0807.
PATRICi23430075. VBISalAre38676_0823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV96726.1 .
RefSeqi YP_001535717.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8M2V8.
SMRi A8M2V8. Positions 13-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_0807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV96726 ; ABV96726 ; Sare_0807 .
GeneIDi 5705201.
KEGGi saq:Sare_0807.
PATRICi 23430075. VBISalAre38676_0823.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci SARE391037:GH66-820-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiPCKG_SALAI
AccessioniPrimary (citable) accession number: A8M2V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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