A8M2R0 (A8M2R0_SALAI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
Ordered Locus Names:	Sare_0759

Organism

Salinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV96678.1

Taxonomic identifier

391037 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540
Ligand	Metal-binding HAMAP MF_00540 Zinc HAMAP MF_00540
Molecular function	Hydrolase HAMAP MF_00540 EMBL ABV96678.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	210	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	19	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	21	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	207	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	297	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	21	1	Substrate By similarity HAMAP MF_00540
	Binding site	23	1	Substrate By similarity HAMAP MF_00540
	Binding site	180	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	231	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	A8M2R0 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: BEE0A13D48E81F52	FASTA	364	39,853
	10 20 30 40 50 60 MVATIRYEDI VQVPKALLHD HLDGGLRPAT VVELAAEAEH ELPTTDPEAL GRWFVDAANS 70 80 90 100 110 120 GSLERYLETF AHTVGVMQTA SSLRRVAREC ALDLASDGVV YAEVRFAPEL HLERDLNLDE 130 140 150 160 170 180 VVAAVIAGFD EGSALAAAAG TPIRVGALLT AMRHAARSQE IAELAVRYRD TGVVGFDIAG 190 200 210 220 230 240 AEAGFPPTRH LDAFEYLQRE NFHFTIHAGE AFGLPSIWQA IQWCGADRLG HGVRIVDDIT 250 260 270 280 290 300 PGPEPVLGRL AAYVRDKRIP LELCPSSNVQ TGATPSIAEH PIGLLRDLRF RVTVNTDNRL 310 320 330 340 350 360 MSGTSMSREM ALLVDTFGYG WRELQWLTIN AMKSAFIPFD QRLQIIDEVI KPAYGRLLTG PGRP

References

[1]

"Complete sequence of Salinispora arenicola CNS-205." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNS-205.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000850 Genomic DNA. Translation: ABV96678.1.
RefSeq	YP_001535669.1. NC_009953.1.
3D structure databases
ProteinModelPortal	A8M2R0.
ModBase	Search...
Protein-protein interaction databases
STRING	A8M2R0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5708278.
GenomeReviews	Gene locus Sare_0759 in contig CP000850_GR.
KEGG	saq:Sare_0759.
PATRIC	23429979. VBISalAre38676_0775.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	PYYMAMN.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	SARE391037:SARE_0759-MONOMER.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8M2R0_SALAI

Accession

Primary (citable) accession number: A8M2R0

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)