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A8M1N1

- ACDH1_SALAI

UniProt

A8M1N1 - ACDH1_SALAI

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Protein
Acetaldehyde dehydrogenase 1
Gene
Sare_3901
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediate By similarity
Binding sitei285 – 2851NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 134NAD By similarity
Nucleotide bindingi159 – 1679NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSARE391037:GH66-3947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene namesi
Ordered Locus Names:Sare_3901
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Acetaldehyde dehydrogenase 1UniRule annotation
PRO_0000387736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_3901.

Structurei

3D structure databases

ProteinModelPortaliA8M1N1.
SMRiA8M1N1. Positions 5-300.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A8M1N1-1 [UniParc]FASTAAdd to Basket

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MSVGVAVLGS GNIGTDLMIK VLRLSDSLRM VAMAGIDSGS DGLARARRLG    50
VTTTADGVAG LVTLPEFADV ELVFDATSAG AHRHHDSVLR AYGRIVVDLT 100
PAAIGPYVVP PVNLDEHLAE TNVNMVTCGG QATVPIVAAI GRVTPVAYGE 150
IVASIASKSA GPGTRANIDE FTETTARAIE VVGGADRGKA IIVLNPADPP 200
LLMRDTVYCL CPDTDADRSA IIAAVTDMVG AVQEYVPGYR LKQEVQFDRV 250
DSYLPALGGH LTGLQVSVFL EVSGAGHYLP EYAGNLDIMT SAALRTAERL 300
IGRRAVTA 308
Length:308
Mass (Da):32,093
Last modified:December 4, 2007 - v1
Checksum:i39BC023A2C35DDC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99692.1.
RefSeqiYP_001538683.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV99692; ABV99692; Sare_3901.
GeneIDi5705839.
KEGGisaq:Sare_3901.
PATRICi23436361. VBISalAre38676_3933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99692.1 .
RefSeqi YP_001538683.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8M1N1.
SMRi A8M1N1. Positions 5-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_3901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV99692 ; ABV99692 ; Sare_3901 .
GeneIDi 5705839.
KEGGi saq:Sare_3901.
PATRICi 23436361. VBISalAre38676_3933.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SARE391037:GH66-3947-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiACDH1_SALAI
AccessioniPrimary (citable) accession number: A8M1N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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