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A8M1N1

- ACDH1_SALAI

UniProt

A8M1N1 - ACDH1_SALAI

Protein

Acetaldehyde dehydrogenase 1

Gene

Sare_3901

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
    Binding sitei285 – 2851NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 134NADUniRule annotation
    Nucleotide bindingi159 – 1679NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSARE391037:GH66-3947-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Ordered Locus Names:Sare_3901
    OrganismiSalinispora arenicola (strain CNS-205)
    Taxonomic identifieri391037 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
    ProteomesiUP000001153: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Acetaldehyde dehydrogenase 1PRO_0000387736Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391037.Sare_3901.

    Structurei

    3D structure databases

    ProteinModelPortaliA8M1N1.
    SMRiA8M1N1. Positions 5-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHQGNVNM.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8M1N1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVGVAVLGS GNIGTDLMIK VLRLSDSLRM VAMAGIDSGS DGLARARRLG    50
    VTTTADGVAG LVTLPEFADV ELVFDATSAG AHRHHDSVLR AYGRIVVDLT 100
    PAAIGPYVVP PVNLDEHLAE TNVNMVTCGG QATVPIVAAI GRVTPVAYGE 150
    IVASIASKSA GPGTRANIDE FTETTARAIE VVGGADRGKA IIVLNPADPP 200
    LLMRDTVYCL CPDTDADRSA IIAAVTDMVG AVQEYVPGYR LKQEVQFDRV 250
    DSYLPALGGH LTGLQVSVFL EVSGAGHYLP EYAGNLDIMT SAALRTAERL 300
    IGRRAVTA 308
    Length:308
    Mass (Da):32,093
    Last modified:December 4, 2007 - v1
    Checksum:i39BC023A2C35DDC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99692.1.
    RefSeqiYP_001538683.1. NC_009953.1.

    Genome annotation databases

    EnsemblBacteriaiABV99692; ABV99692; Sare_3901.
    GeneIDi5705839.
    KEGGisaq:Sare_3901.
    PATRICi23436361. VBISalAre38676_3933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99692.1 .
    RefSeqi YP_001538683.1. NC_009953.1.

    3D structure databases

    ProteinModelPortali A8M1N1.
    SMRi A8M1N1. Positions 5-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391037.Sare_3901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV99692 ; ABV99692 ; Sare_3901 .
    GeneIDi 5705839.
    KEGGi saq:Sare_3901.
    PATRICi 23436361. VBISalAre38676_3933.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HQGNVNM.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci SARE391037:GH66-3947-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNS-205.

    Entry informationi

    Entry nameiACDH1_SALAI
    AccessioniPrimary (citable) accession number: A8M1N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3