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A8M1N1 (ACDH1_SALAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Ordered Locus Names:Sare_3901
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP]
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Acetaldehyde dehydrogenase 1 HAMAP MF_01657
PRO_0000387736

Regions

Nucleotide binding10 – 134NAD By similarity
Nucleotide binding159 – 1679NAD By similarity

Sites

Binding site2851NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A8M1N1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 39BC023A2C35DDC6

FASTA30832,093
        10         20         30         40         50         60 
MSVGVAVLGS GNIGTDLMIK VLRLSDSLRM VAMAGIDSGS DGLARARRLG VTTTADGVAG 

        70         80         90        100        110        120 
LVTLPEFADV ELVFDATSAG AHRHHDSVLR AYGRIVVDLT PAAIGPYVVP PVNLDEHLAE 

       130        140        150        160        170        180 
TNVNMVTCGG QATVPIVAAI GRVTPVAYGE IVASIASKSA GPGTRANIDE FTETTARAIE 

       190        200        210        220        230        240 
VVGGADRGKA IIVLNPADPP LLMRDTVYCL CPDTDADRSA IIAAVTDMVG AVQEYVPGYR 

       250        260        270        280        290        300 
LKQEVQFDRV DSYLPALGGH LTGLQVSVFL EVSGAGHYLP EYAGNLDIMT SAALRTAERL 


IGRRAVTA

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV99692.1.
RefSeqYP_001538683.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8M1N1.
SMRA8M1N1. Positions 5-300.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8M1N1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5705839.
GenomeReviewsGene locus Sare_3901 in contig CP000850_GR.
KEGGsaq:Sare_3901.
PATRIC23436361. VBISalAre38676_3933.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG300125.
OMAHVKNDAF.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycSARE391037:SARE_3901-MONOMER.

Family and domain databases

HAMAPMF_01657. Ac_ald_DH_ac.
[Tree]
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK04073.
PANTHERPTHR21123. Acetylald_dh. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_SALAI
AccessionPrimary (citable) accession number: A8M1N1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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