A8M183 (A8M183_SALAI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Quorum-sensing autoinducer 2 (AI-2), LuxS EMBL ABV96553.1

Gene names

Ordered Locus Names:

Sare_0630

Organism

Salinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV96553.1

Taxonomic identifier

391037 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Lyase SAAS SAAS003815
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8M183 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 09F5287425866209	FASTA	165	18,493
	10 20 30 40 50 60 MTSRDLDHRY VVPPYLRVVT EQTVPGTDQR VALWDFRVAQ PNASHVPGPV MHSLEHFLGT 70 80 90 100 110 120 YVRTHHPTIM NVAPMGCMTG LYVWTVGEWN FDDLADVITA GLRSIRDADE VPLANIVQCG 130 140 150 160 WAEHHSLEGV KEFAERLLAD RDQWRDPGPD AHEVSAADLR ELSAG

References

[1]

"Complete sequence of Salinispora arenicola CNS-205." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNS-205.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000850 Genomic DNA. Translation: ABV96553.1.
RefSeq	YP_001535544.1. NC_009953.1.
3D structure databases
ProteinModelPortal	A8M183.
ModBase	Search...
Protein-protein interaction databases
STRING	A8M183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5707137.
GenomeReviews	Gene locus Sare_0630 in contig CP000850_GR.
KEGG	saq:Sare_0630.
PATRIC	23429713. VBISalAre38676_0644.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG347473.
OMA	PHGDTIT.
ProtClustDB	CLSK968694.
Enzyme and pathway databases
BioCyc	SARE391037:SARE_0630-MONOMER.
Family and domain databases
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8M183_SALAI

Accession

Primary (citable) accession number: A8M183

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)