Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8M0V6 (A8M0V6_SALAI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109
EC=1.1.1.44 PIRNR PIRNR000109
Gene names
Ordered Locus Names:Sare_3824
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV99617.1
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109

Ontologies

Keywords
   Biological processPentose shunt PIRNR PIRNR000109
   LigandNADP PIRNR PIRNR000109
   Molecular functionOxidoreductase PIRNR PIRNR000109
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 166NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding34 – 363NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding76 – 783NADP By similarity PIRSR PIRSR000109-3
Region130 – 1323Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1041NADP By similarity PIRSR PIRSR000109-3
Binding site1041Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2621Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2891Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A8M0V6 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: FA5EAE26B5C03A74

FASTA47851,802
        10         20         30         40         50         60 
MSGQAQIGVT GLAVMGRNLA RNLARNGLTV AVHNRSPERT RGLVAEHGDE GRFVPTESMA 

        70         80         90        100        110        120 
DFVAALERPR AVIMMVKAGG PTDAVIDELV PLLDAGDIIV DCGNAHFADT RRREEALRRH 

       130        140        150        160        170        180 
DLHFVGTGVS GGEEGALWGP SIMPGGSAES YRKLGPIFER IAAQVDGEPC CRHIGPDGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYADMQLIAE AYDLLRAGLD ATPAELAETF RQWNSGELES FLIEITADVL 

       250        260        270        280        290        300 
GHTDASTGQA FVDVVLDQAE QKGTGRWTVQ SALDLGIPIT GIAEATFARS LSGHADQREA 

       310        320        330        340        350        360 
TRRAFAGTGP AWQVADRDTF VEDVRRALLA SKIVAYAQGF DHIRAGSQEY DWNIDLGGTA 

       370        380        390        400        410        420 
TIWRGGCIIR ARFLDRIRQA YDDHPDLPTL LVAPWFADTV RDGVPGWRRV VAEAAQAGVP 

       430        440        450        460        470 
TPAFASSLSY FDALRANRLP AALIQGLRDN FGAHTYRRVD RDGSFHTIWA GDHHEVEA

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV99617.1.
RefSeqYP_001538608.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8M0V6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8M0V6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5703786.
GenomeReviewsGene locus Sare_3824 in contig CP000850_GR.
KEGGsaq:Sare_3824.
PATRIC23436191. VBISalAre38676_3853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycSARE391037:SARE_3824-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8M0V6_SALAI
AccessionPrimary (citable) accession number: A8M0V6
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info