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Protein

Catalase-peroxidase

Gene

katG

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei125Transition state stabilizerUniRule annotation1
Active sitei129Proton acceptorUniRule annotation1
Metal bindingi291Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-2196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sare_2160
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549021 – 758Catalase-peroxidaseAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki128 ↔ 250Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-276)UniRule annotation
Cross-linki250 ↔ 276Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-128)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA8M0L5

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_2160

Structurei

3D structure databases

ProteinModelPortaliA8M0L5
SMRiA8M0L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

A8M0L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTQDNAPA SAQGVDQKAA AGCPVAHDSV TAHGSESESP AIDSPTPHSG
60 70 80 90 100
GRPRTNRDWW PNQLDLSVLS TNSAKVNPLG EDFAYAKEFA KLDVEALKRD
110 120 130 140 150
IVEVLTTSQD WWPADFGHYG GLMIRLSWHA AGTYRIDDGR GGAGDGGQRF
160 170 180 190 200
APLNSWPDNV NLDKARRLLW PVKQKYGQKI SWADLLVLAG NVALESMGFK
210 220 230 240 250
TFGFGFGRED VWEPEEIFWG SEDTWVGDER YVSEKEFVAG VGATEMGLIY
260 270 280 290 300
VNPEGPRGNA DPAAAAHFIR ETFRRMAMDD EETVALIAGG HTFGKTHGAG
310 320 330 340 350
IADDHVGPEP EAAPLEAQGL GWMSSYASGA GADAISSGLE VTWTDRPTQW
360 370 380 390 400
SNRFFEILFA YEWELTTSPG GAKQWVAKDA EAIIPDAYDA AKKHKPTMLT
410 420 430 440 450
TDLSLRVDPA YERISRRFLE NPDEFALAFA KAWYKLLHRD MGPVSRFLGP
460 470 480 490 500
WVPEPQLWQD PVPAVDHALV GDADIAALKA KVLQSGLTTA QLVSTAWASA
510 520 530 540 550
ASFRHTDRRG GANGARVRLE PQRGWEVNQP EQLATVLTTL EGIQREFNAA
560 570 580 590 600
GGTKISLADL IVLAGSAAVE KAARDAGFEV TVPFHPGRTD ATQEQTDVES
610 620 630 640 650
FQVLEPRADG FRNYLRPGEK AQPEVLLVDR AYMLNLTAPE MTVLIGGLRA
660 670 680 690 700
LEANVGGSRH GVLTDRPGVL TNDFFTNLLA LGTRWKASES TEHVYEIRDL
710 720 730 740 750
ATDTVKWTAS AVDLIFGSNS QLRALAEVYA SEDAREKFVT DFVAAWTKVM

ELDRFDLA
Length:758
Mass (Da):82,846
Last modified:December 4, 2007 - v1
Checksum:iE98A606AA35F0D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV98025.1
RefSeqiWP_012182327.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV98025; ABV98025; Sare_2160
GeneIDi5705616
KEGGisaq:Sare_2160
PATRICifig|391037.6.peg.2185

Similar proteinsi

Entry informationi

Entry nameiKATG_SALAI
AccessioniPrimary (citable) accession number: A8M0L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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