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Protein

Catalase-peroxidase

Gene

katG

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei125 – 1251Transition state stabilizerUniRule annotation
Active sitei129 – 1291Proton acceptorUniRule annotation
Metal bindingi291 – 2911Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-2192-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sare_2160
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Catalase-peroxidasePRO_0000354902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki128 ↔ 250Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-276)UniRule annotation
Cross-linki250 ↔ 276Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-128)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_2160.

Structurei

3D structure databases

ProteinModelPortaliA8M0L5.
SMRiA8M0L5. Positions 55-758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8M0L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTQDNAPA SAQGVDQKAA AGCPVAHDSV TAHGSESESP AIDSPTPHSG
60 70 80 90 100
GRPRTNRDWW PNQLDLSVLS TNSAKVNPLG EDFAYAKEFA KLDVEALKRD
110 120 130 140 150
IVEVLTTSQD WWPADFGHYG GLMIRLSWHA AGTYRIDDGR GGAGDGGQRF
160 170 180 190 200
APLNSWPDNV NLDKARRLLW PVKQKYGQKI SWADLLVLAG NVALESMGFK
210 220 230 240 250
TFGFGFGRED VWEPEEIFWG SEDTWVGDER YVSEKEFVAG VGATEMGLIY
260 270 280 290 300
VNPEGPRGNA DPAAAAHFIR ETFRRMAMDD EETVALIAGG HTFGKTHGAG
310 320 330 340 350
IADDHVGPEP EAAPLEAQGL GWMSSYASGA GADAISSGLE VTWTDRPTQW
360 370 380 390 400
SNRFFEILFA YEWELTTSPG GAKQWVAKDA EAIIPDAYDA AKKHKPTMLT
410 420 430 440 450
TDLSLRVDPA YERISRRFLE NPDEFALAFA KAWYKLLHRD MGPVSRFLGP
460 470 480 490 500
WVPEPQLWQD PVPAVDHALV GDADIAALKA KVLQSGLTTA QLVSTAWASA
510 520 530 540 550
ASFRHTDRRG GANGARVRLE PQRGWEVNQP EQLATVLTTL EGIQREFNAA
560 570 580 590 600
GGTKISLADL IVLAGSAAVE KAARDAGFEV TVPFHPGRTD ATQEQTDVES
610 620 630 640 650
FQVLEPRADG FRNYLRPGEK AQPEVLLVDR AYMLNLTAPE MTVLIGGLRA
660 670 680 690 700
LEANVGGSRH GVLTDRPGVL TNDFFTNLLA LGTRWKASES TEHVYEIRDL
710 720 730 740 750
ATDTVKWTAS AVDLIFGSNS QLRALAEVYA SEDAREKFVT DFVAAWTKVM

ELDRFDLA
Length:758
Mass (Da):82,846
Last modified:December 4, 2007 - v1
Checksum:iE98A606AA35F0D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV98025.1.
RefSeqiWP_012182327.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV98025; ABV98025; Sare_2160.
GeneIDi5705616.
KEGGisaq:Sare_2160.
PATRICi23432838. VBISalAre38676_2185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV98025.1.
RefSeqiWP_012182327.1. NC_009953.1.

3D structure databases

ProteinModelPortaliA8M0L5.
SMRiA8M0L5. Positions 55-758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391037.Sare_2160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV98025; ABV98025; Sare_2160.
GeneIDi5705616.
KEGGisaq:Sare_2160.
PATRICi23432838. VBISalAre38676_2185.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciSARE391037:GH66-2192-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SALAI
AccessioniPrimary (citable) accession number: A8M0L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.