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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei291D-inositol 3-phosphateUniRule annotation1
Binding sitei43UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei981D-inositol 3-phosphateUniRule annotation1
Binding sitei1311D-inositol 3-phosphateUniRule annotation1
Binding sitei1551D-inositol 3-phosphateUniRule annotation1
Binding sitei1751D-inositol 3-phosphateUniRule annotation1
Binding sitei255UDP-GlcNAcUniRule annotation1
Binding sitei260UDP-GlcNAcUniRule annotation1
Binding sitei321UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi330Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi331Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi333Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei343UDP-GlcNAcUniRule annotation1
Binding sitei351UDP-GlcNAcUniRule annotation1
Metal bindingi357MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Sare_0398
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001551 – 448D-inositol 3-phosphate glycosyltransferaseAdd BLAST448

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_0398.

Structurei

3D structure databases

ProteinModelPortaliA8LZG1.
SMRiA8LZG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 36UDP-GlcNAc bindingUniRule annotation2
Regioni40 – 451D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQHTGVGR QRGARPWPRP RRVATLSVHT SPLHQPGTGD AGGMNVYILE
60 70 80 90 100
VARRLAEADV EVEIFTRATS ADVPPVVEMM PGVHVRNIIS GPLGGLTKEE
110 120 130 140 150
LPGQLCAFTA GVLRAEASRA AGHYDLIHSH YWLSGQVGWL AKERWGVPLV
160 170 180 190 200
HTAHTLAKVK NAQLAAGDRP EPKARVIGEE QVVAEADRLV ANTKTEAGDL
210 220 230 240 250
IDRYDADPTR VEVVEPGVDL ARFTPAAGDR SRAQALARRR LGLPERGYVV
260 270 280 290 300
AFVGRVQPLK APDVLIRAAA ALRQRDPALA EELTVVVCGG PSGSGLDRPT
310 320 330 340 350
HLIELAASLG VTDSVRFLPP QTGDDLPALY RAADLVAVPS YNESFGLVAL
360 370 380 390 400
EAQACGTPVV AAAVGGLVTA VRDQVSGVLV DGHDPAVWAR TLSRLLPDTG
410 420 430 440
LRATLAQGAR RHACNFSWDR TVSGLLEVYG EAVAAYGPQS SELATCSC
Length:448
Mass (Da):47,533
Last modified:December 4, 2007 - v1
Checksum:i9ED4733A4BAFBD6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV96327.1.
RefSeqiWP_012180601.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV96327; ABV96327; Sare_0398.
GeneIDi5705657.
KEGGisaq:Sare_0398.
PATRICi23429231. VBISalAre38676_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV96327.1.
RefSeqiWP_012180601.1. NC_009953.1.

3D structure databases

ProteinModelPortaliA8LZG1.
SMRiA8LZG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391037.Sare_0398.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV96327; ABV96327; Sare_0398.
GeneIDi5705657.
KEGGisaq:Sare_0398.
PATRICi23429231. VBISalAre38676_0405.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_SALAI
AccessioniPrimary (citable) accession number: A8LZG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.