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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei291D-inositol 3-phosphateUniRule annotation1
Binding sitei43UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei981D-inositol 3-phosphateUniRule annotation1
Binding sitei1311D-inositol 3-phosphateUniRule annotation1
Binding sitei1551D-inositol 3-phosphateUniRule annotation1
Binding sitei1751D-inositol 3-phosphateUniRule annotation1
Binding sitei255UDP-GlcNAcUniRule annotation1
Binding sitei260UDP-GlcNAcUniRule annotation1
Binding sitei321UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi330Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi331Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi333Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei343UDP-GlcNAcUniRule annotation1
Binding sitei351UDP-GlcNAcUniRule annotation1
Metal bindingi357MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-410-MONOMER

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Sare_0398
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001551 – 448D-inositol 3-phosphate glycosyltransferaseAdd BLAST448

Proteomic databases

PRIDEiA8LZG1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391037.Sare_0398

Structurei

3D structure databases

ProteinModelPortaliA8LZG1
SMRiA8LZG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 36UDP-GlcNAc bindingUniRule annotation2
Regioni40 – 451D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

A8LZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQHTGVGR QRGARPWPRP RRVATLSVHT SPLHQPGTGD AGGMNVYILE
60 70 80 90 100
VARRLAEADV EVEIFTRATS ADVPPVVEMM PGVHVRNIIS GPLGGLTKEE
110 120 130 140 150
LPGQLCAFTA GVLRAEASRA AGHYDLIHSH YWLSGQVGWL AKERWGVPLV
160 170 180 190 200
HTAHTLAKVK NAQLAAGDRP EPKARVIGEE QVVAEADRLV ANTKTEAGDL
210 220 230 240 250
IDRYDADPTR VEVVEPGVDL ARFTPAAGDR SRAQALARRR LGLPERGYVV
260 270 280 290 300
AFVGRVQPLK APDVLIRAAA ALRQRDPALA EELTVVVCGG PSGSGLDRPT
310 320 330 340 350
HLIELAASLG VTDSVRFLPP QTGDDLPALY RAADLVAVPS YNESFGLVAL
360 370 380 390 400
EAQACGTPVV AAAVGGLVTA VRDQVSGVLV DGHDPAVWAR TLSRLLPDTG
410 420 430 440
LRATLAQGAR RHACNFSWDR TVSGLLEVYG EAVAAYGPQS SELATCSC
Length:448
Mass (Da):47,533
Last modified:December 4, 2007 - v1
Checksum:i9ED4733A4BAFBD6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA Translation: ABV96327.1
RefSeqiWP_012180601.1, NC_009953.1

Genome annotation databases

EnsemblBacteriaiABV96327; ABV96327; Sare_0398
GeneIDi5705657
KEGGisaq:Sare_0398
PATRICifig|391037.6.peg.405

Similar proteinsi

Entry informationi

Entry nameiMSHA_SALAI
AccessioniPrimary (citable) accession number: A8LZG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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