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A8LYU3 (DER_SALAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:Sare_1921
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP]
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467GTPase Der HAMAP MF_00195
PRO_1000077669

Regions

Domain36 – 141106G 1
Domain210 – 318109G 2
Domain372 – 45584KH-like
Nucleotide binding31 – 388GTP 1 Potential
Nucleotide binding78 – 825GTP 1 Potential
Nucleotide binding140 – 1434GTP 1 Potential
Nucleotide binding205 – 2128GTP 2 Potential
Nucleotide binding252 – 2565GTP 2 Potential
Nucleotide binding317 – 3204GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
A8LYU3 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 8F1862382513556B

FASTA46750,411
        10         20         30         40         50         60 
MSEPNGWVEL DVPEPDAEEF TGPQPVVAVV GRPNVGKSTL VNRLIGRRQA VVEDVPGVTR 

        70         80         90        100        110        120 
DRVPYDAQWN GRQFAVVDTG GWEPDAKDRA AAIAAQAETA VTTADVVLFV VDAVVGATDV 

       130        140        150        160        170        180 
DESAVKMLRR SAKPVILVAN KADNSSIEME AATLWSLGLG EPYPVSALHG RGSGELLDVI 

       190        200        210        220        230        240 
MDRLPEAPKI IEDRPRGPRR VALVGRPNVG KSSLLNRFSG EVRAVVDAVA GTTVDPVDSL 

       250        260        270        280        290        300 
VEIGGEAWQL VDTAGLRKRV GKASGTEYYA SLRTASAIEA AEVAVVLLDA SEVISEQDQR 

       310        320        330        340        350        360 
ILSMVTDAGR ALVIAFNKWD LVDADRRYYL DREIERELRR IPWAIRLNLS AKTGRAVDKL 

       370        380        390        400        410        420 
APALRKALAS WETRVPTAQL NAWLTALVQA TPHPVRGGRA PKILFATQAG AAPPRFVLFT 

       430        440        450        460 
SGPLDAGYQR FVERKLREEF GFEGSPIEIA VRPRKKVGPG GRGKAHG

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV97806.1.
RefSeqYP_001536797.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8LYU3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LYU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5708273.
GenomeReviewsGene locus Sare_1921 in contig CP000850_GR.
KEGGsaq:Sare_1921.
PATRIC23432366. VBISalAre38676_1950.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG592135.
OMALAVNKCE.
ProtClustDBPRK03003.

Enzyme and pathway databases

BioCycSARE391037:SARE_1921-MONOMER.

Family and domain databases

HAMAPMF_00195. GTPase_Der.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.300.20. KH_prok. 1 hit.
KOK03977.
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. Small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_SALAI
AccessionPrimary (citable) accession number: A8LYU3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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