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A8LYF4

- LIPB_SALAI

UniProt

A8LYF4 - LIPB_SALAI

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Protein
Octanoyltransferase
Gene
lipB, Sare_3560
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate By similarity.UniRule annotation

Catalytic activityi

Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei142 – 1421Lowers pKa of active site Cys By similarity
Active sitei176 – 1761Acyl-thioester intermediate By similarity

GO - Molecular functioni

  1. lipoyl(octanoyl) transferase activity Source: UniProtKB-EC
  2. octanoyltransferase activity Source: InterPro

GO - Biological processi

  1. cellular protein modification process Source: InterPro
  2. lipoate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSARE391037:GH66-3597-MONOMER.
UniPathwayiUPA00538; UER00592.

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyltransferase (EC:2.3.1.181)
Alternative name(s):
Lipoate-protein ligase B
Lipoyl/octanoyl transferase
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Gene namesi
Name:lipB
Ordered Locus Names:Sare_3560
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213OctanoyltransferaseUniRule annotation
PRO_1000074012Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_3560.

Structurei

3D structure databases

ProteinModelPortaliA8LYF4.
SMRiA8LYF4. Positions 6-196.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 808Substrate binding By similarity
Regioni145 – 1473Substrate binding By similarity
Regioni158 – 1603Substrate binding By similarity

Sequence similaritiesi

Belongs to the LipB family.

Phylogenomic databases

eggNOGiCOG0321.
HOGENOMiHOG000194322.
KOiK03801.
OMAiEPHERPL.
OrthoDBiEOG6XM7G6.

Family and domain databases

HAMAPiMF_00013. LipB.
InterProiIPR004143. BPL_LipA_LipB.
IPR000544. Octanoyltransferase.
IPR020605. Octanoyltransferase_CS.
[Graphical view]
PfamiPF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
PIRSFiPIRSF016262. LPLase. 1 hit.
TIGRFAMsiTIGR00214. lipB. 1 hit.
PROSITEiPS01313. LIPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LYF4-1 [UniParc]FASTAAdd to Basket

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MTTTTSDLTV LRAGTLDYEA AWEEQRRLHE SVVTDKHGDA VLLLEHPSVY    50
TAGKRTEPWD RPMDGTPVID VDRGGKITWH GPGQLVGYPI LRLPDPVDVV 100
AYVRRVEQML IDVCAEFGLV AGRIEGRSGV WVPADDRGPA RKVAAIGIRV 150
ARGVTLHGFS LNCDCDLTYY DRIVPCGIRD AGVTSLAAEL GRPVTVADAL 200
PVVERHLPTL VGA 213
Length:213
Mass (Da):23,142
Last modified:December 4, 2007 - v1
Checksum:i18FDF8D654137190
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99362.1.
RefSeqiYP_001538353.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV99362; ABV99362; Sare_3560.
GeneIDi5705053.
KEGGisaq:Sare_3560.
PATRICi23435655. VBISalAre38676_3588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99362.1 .
RefSeqi YP_001538353.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8LYF4.
SMRi A8LYF4. Positions 6-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_3560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV99362 ; ABV99362 ; Sare_3560 .
GeneIDi 5705053.
KEGGi saq:Sare_3560.
PATRICi 23435655. VBISalAre38676_3588.

Phylogenomic databases

eggNOGi COG0321.
HOGENOMi HOG000194322.
KOi K03801.
OMAi EPHERPL.
OrthoDBi EOG6XM7G6.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00592 .
BioCyci SARE391037:GH66-3597-MONOMER.

Family and domain databases

HAMAPi MF_00013. LipB.
InterProi IPR004143. BPL_LipA_LipB.
IPR000544. Octanoyltransferase.
IPR020605. Octanoyltransferase_CS.
[Graphical view ]
Pfami PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view ]
PIRSFi PIRSF016262. LPLase. 1 hit.
TIGRFAMsi TIGR00214. lipB. 1 hit.
PROSITEi PS01313. LIPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiLIPB_SALAI
AccessioniPrimary (citable) accession number: A8LYF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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