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A8LYF4

- LIPB_SALAI

UniProt

A8LYF4 - LIPB_SALAI

Protein

Octanoyltransferase

Gene

lipB

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.UniRule annotation

    Catalytic activityi

    Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei142 – 1421Lowers pKa of active site CysUniRule annotation
    Active sitei176 – 1761Acyl-thioester intermediateUniRule annotation

    GO - Molecular functioni

    1. lipoyl(octanoyl) transferase activity Source: UniProtKB-EC
    2. octanoyltransferase activity Source: InterPro

    GO - Biological processi

    1. cellular protein modification process Source: InterPro
    2. lipoate biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSARE391037:GH66-3597-MONOMER.
    UniPathwayiUPA00538; UER00592.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OctanoyltransferaseUniRule annotation (EC:2.3.1.181UniRule annotation)
    Alternative name(s):
    Lipoate-protein ligase BUniRule annotation
    Lipoyl/octanoyl transferaseUniRule annotation
    Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferaseUniRule annotation
    Gene namesi
    Name:lipBUniRule annotation
    Ordered Locus Names:Sare_3560
    OrganismiSalinispora arenicola (strain CNS-205)
    Taxonomic identifieri391037 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
    ProteomesiUP000001153: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213OctanoyltransferasePRO_1000074012Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391037.Sare_3560.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LYF4.
    SMRiA8LYF4. Positions 6-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 808Substrate bindingUniRule annotation
    Regioni145 – 1473Substrate bindingUniRule annotation
    Regioni158 – 1603Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the LipB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0321.
    HOGENOMiHOG000194322.
    KOiK03801.
    OMAiEPHERPL.
    OrthoDBiEOG6XM7G6.

    Family and domain databases

    HAMAPiMF_00013. LipB.
    InterProiIPR004143. BPL_LipA_LipB.
    IPR000544. Octanoyltransferase.
    IPR020605. Octanoyltransferase_CS.
    [Graphical view]
    PfamiPF03099. BPL_LplA_LipB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016262. LPLase. 1 hit.
    TIGRFAMsiTIGR00214. lipB. 1 hit.
    PROSITEiPS01313. LIPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8LYF4-1 [UniParc]FASTAAdd to Basket

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    MTTTTSDLTV LRAGTLDYEA AWEEQRRLHE SVVTDKHGDA VLLLEHPSVY    50
    TAGKRTEPWD RPMDGTPVID VDRGGKITWH GPGQLVGYPI LRLPDPVDVV 100
    AYVRRVEQML IDVCAEFGLV AGRIEGRSGV WVPADDRGPA RKVAAIGIRV 150
    ARGVTLHGFS LNCDCDLTYY DRIVPCGIRD AGVTSLAAEL GRPVTVADAL 200
    PVVERHLPTL VGA 213
    Length:213
    Mass (Da):23,142
    Last modified:December 4, 2007 - v1
    Checksum:i18FDF8D654137190
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99362.1.
    RefSeqiYP_001538353.1. NC_009953.1.

    Genome annotation databases

    EnsemblBacteriaiABV99362; ABV99362; Sare_3560.
    GeneIDi5705053.
    KEGGisaq:Sare_3560.
    PATRICi23435655. VBISalAre38676_3588.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99362.1 .
    RefSeqi YP_001538353.1. NC_009953.1.

    3D structure databases

    ProteinModelPortali A8LYF4.
    SMRi A8LYF4. Positions 6-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391037.Sare_3560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV99362 ; ABV99362 ; Sare_3560 .
    GeneIDi 5705053.
    KEGGi saq:Sare_3560.
    PATRICi 23435655. VBISalAre38676_3588.

    Phylogenomic databases

    eggNOGi COG0321.
    HOGENOMi HOG000194322.
    KOi K03801.
    OMAi EPHERPL.
    OrthoDBi EOG6XM7G6.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00592 .
    BioCyci SARE391037:GH66-3597-MONOMER.

    Family and domain databases

    HAMAPi MF_00013. LipB.
    InterProi IPR004143. BPL_LipA_LipB.
    IPR000544. Octanoyltransferase.
    IPR020605. Octanoyltransferase_CS.
    [Graphical view ]
    Pfami PF03099. BPL_LplA_LipB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016262. LPLase. 1 hit.
    TIGRFAMsi TIGR00214. lipB. 1 hit.
    PROSITEi PS01313. LIPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNS-205.

    Entry informationi

    Entry nameiLIPB_SALAI
    AccessioniPrimary (citable) accession number: A8LYF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3