A8LY60 (A8LY60_SALAI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Sare_3466

Organism

Salinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV99268.1

Taxonomic identifier

391037 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length	1124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8LY60 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 8BF18781F6054D06	FASTA	1,124	122,276
	10 20 30 40 50 60 MSFHNPDLPW SELERVLTGR PARGQRRTQD GERHLHVVDP LAVDADGGDA AAWAGKRQHR 70 80 90 100 110 120 TPPAVSRPDD AVPYAELHTH TNFSFLDGAS HPEELAEEAT RLGLTALAVT DHDGFYGVVR 130 140 150 160 170 180 FAEAARALHL PTIFGAELSL DLPGPPNGEP DPLGRHLLLL AHGHEGYARL AATISRAQLR 190 200 210 220 230 240 GGEKGRPVYG ELAEVAAELR DHVLVLTGCR KGHVPAALLT EGVDAAAREL DRLTALFGAE 250 260 270 280 290 300 TVAVELTDHG HPVDADRNDA LAELADAAGL PTVATNNVHY ATPGRRRLAT TLAAVRARRS 310 320 330 340 350 360 LDEIDGWLPA AGTAHLRSGA EMAARFAAYP GAVARAAEFG AELAFDLQLV APALPAYPVP 370 380 390 400 410 420 SGHTEMSWLR HLTARGARER YGPPEAHPEA YAQLEHELNM IEELGFPGYF LVVYDIVTFC 430 440 450 460 470 480 REQDIYCQGR GSAANSAVCY ALRITNVDAV RHRLLFERFL APERDGPPDI DVDIESHRRE 490 500 510 520 530 540 EVIQHVYARY GREHTAQVAN VISYRPRSAV RDVAKAFGFS PGQQDAWSKQ VDRWGSVAEV 550 560 570 580 590 600 DAEGIPEPVV AYADAVQTFP RHLGIHSGGM VICDRPVIEV CPVEWGRMPG RSVLQWDKDD 610 620 630 640 650 660 CAAVGLVKFD LLGLGMLAAL HHGYDMIGTR LELGDMTLDD SEVYDMLCRA DAVGVFQVES 670 680 690 700 710 720 RAQMATLPRL RPRCFYDLVV EVALIRPGPI QGGSVHPYIR RKNGQEPVTY PHPLMRNALE 730 740 750 760 770 780 KTLGVPLFQE QLMQLAIDLA GFDAAEADQL RRAMGAKRSV ERMARIADRL YAGMAERGIT 790 800 810 820 830 840 GELADDVYRK LTAFASYGFP ESHAMSFAYL VYASSWLKRY HPAPFLAALL NAQPMGFYSP 850 860 870 880 890 900 QTLVDDARRH GVEVRRPDVN ASGAGAVLES TPNTRWGSQP GEPPHAWGLG GPAVRLGLDG 910 920 930 940 950 960 VRALGAEVAE RIVAERTAHG LYQDMSDLAR RAGLTAAQLE ALATADAFAC FGVTRRQALW 970 980 990 1000 1010 1020 AAGAAAQDRP DRLPGTVPGT VAPTLPGMAA VDRLVADVWA TGLSPESHPA RFIRDQLDAL 1030 1040 1050 1060 1070 1080 GAVPIDQLAR VEPGRRIRVG GIVTHRQRPA TAGGVTFLNL EDETGMLNVT CSPGLWQRYR 1090 1100 1110 1120 QVAKSSGALV VRGLLQRYDG VINLIADRLD PIDLQVRLAA RDFR

References

[1]

"Complete sequence of Salinispora arenicola CNS-205." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CNS-205.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000850 Genomic DNA. Translation: ABV99268.1.
RefSeq	YP_001538259.1. NC_009953.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8LY60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5708068.
GenomeReviews	Gene locus Sare_3466 in contig CP000850_GR.
KEGG	saq:Sare_3466.
PATRIC	23435467. VBISalAre38676_3494.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Enzyme and pathway databases
BioCyc	SARE391037:SARE_3466-MONOMER.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8LY60_SALAI

Accession

Primary (citable) accession number: A8LY60

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)