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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciSARE391037:G1GA7-1889-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Sare_1862
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000001153 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000773161 – 308Methionyl-tRNA formyltransferaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_1862.

Structurei

3D structure databases

ProteinModelPortaliA8LY30.
SMRiA8LY30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR037022. Formyl_trans_C_sf.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR011034. Formyl_transferase-like_C_sf.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LY30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIFAGTPA VAIPALAAVA DSRHELLAVV TRPDAPAGRG RGLSRSPVAA
60 70 80 90 100
WADEQGVEVL TPARPREPEF LDRLRALAPD CVPVVAYGAL VPPVALEIPQ
110 120 130 140 150
HGWVNLHFSL LPAWRGAAPV QHAVLHGDEL TGASVFQLEQ GLDTGPVYGT
160 170 180 190 200
LTDEVGPADT SGDLLERLAH SGAGLLTAVL DAIEDGTARA EPQPVDGVSL
210 220 230 240 250
APKLTVADAR VRWGDPAFAV DRRVRACTPA PGPWTTFRDE RVKLGPVTPV
260 270 280 290 300
ADGPELKPGE LLVERSRVLA GTATTPVRLG EVRAAGKRAM PASDWARGVR

VTVGEVLA
Length:308
Mass (Da):32,315
Last modified:December 4, 2007 - v1
Checksum:i049184E0ACE11D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV97747.1.
RefSeqiWP_012182051.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV97747; ABV97747; Sare_1862.
GeneIDi5704820.
KEGGisaq:Sare_1862.
PATRICifig|391037.6.peg.1890.

Similar proteinsi

Entry informationi

Entry nameiFMT_SALAI
AccessioniPrimary (citable) accession number: A8LY30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome