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A8LY20

- PYRF_SALAI

UniProt

A8LY20 - PYRF_SALAI

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Sare_1852
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSARE391037:GH66-1880-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Sare_1852
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000085577Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_1852.

Structurei

3D structure databases

ProteinModelPortaliA8LY20.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245748.
KOiK01591.
OMAiGSTMGAY.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LY20-1 [UniParc]FASTAAdd to Basket

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MESFGARLHR AVAERGPLCV GIDPHPGLLA RWGLDDDVHG LERFADTVVE    50
ALGDRVAVVK PQSAFFERFG SRGVAVLEST IRQLRLAGSL VLLDVKRGDI 100
GSTVAAYASA YLEPSSPLHV DAVTVSPYLG VGALAPMFDM AAAKGGGVFV 150
LALTSNPEGA AVQRARTAGG RTVAQVVIDE ISQLNAGAQP LGSVGLVVGA 200
TIGETGHDLA AVNGPLLAPG LGAQGASAAD LRVVFGSALP AVLPAYSREV 250
LAAGPDVAAL RAAADRVLAD CRAALTGS 278
Length:278
Mass (Da):28,171
Last modified:December 4, 2007 - v1
Checksum:iF8DC107CF37CC3E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV97737.1.
RefSeqiYP_001536728.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV97737; ABV97737; Sare_1852.
GeneIDi5704787.
KEGGisaq:Sare_1852.
PATRICi23432220. VBISalAre38676_1880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV97737.1 .
RefSeqi YP_001536728.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8LY20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_1852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV97737 ; ABV97737 ; Sare_1852 .
GeneIDi 5704787.
KEGGi saq:Sare_1852.
PATRICi 23432220. VBISalAre38676_1880.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245748.
KOi K01591.
OMAi GSTMGAY.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SARE391037:GH66-1880-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiPYRF_SALAI
AccessioniPrimary (citable) accession number: A8LY20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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