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A8LXM8 (A8LXM8_SALAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
EC=6.3.5.3 HAMAP-Rule MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420
Gene names
Name:purL HAMAP-Rule MF_00420
Ordered Locus Names:Sare_0159
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP] EMBL ABV96094.1
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora ›

Protein attributes

Sequence length849 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP-Rule MF_00420
   Cellular componentCytoplasm HAMAP-Rule MF_00420
   LigandATP-binding HAMAP-Rule MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP-Rule MF_00420 EMBL ABV96094.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding146 – 15712ATP By similarity HAMAP-Rule MF_00420

Sequences

Sequence LengthMass (Da)Tools
A8LXM8 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 0792FCD185B942C0

FASTA84989,083
        10         20         30         40         50         60 
MTTQDPVRDS DAAVAGPTAA PDRDATVIGW VGGVDTVPHA GDSPDELQPY AELGLRDDEY 

        70         80         90        100        110        120 
ARIRQLLNRR PTQAELAMYS IMWSEHCSYK SSKVHLRQFG EKAPSSDRML AGIGENAGVV 

       130        140        150        160        170        180 
RVSDELAVTF KVESHNHPSF VEPHQGAATG VGGIVRDILA MGARPVAVMD PLRFGAADHP 

       190        200        210        220        230        240 
DTARVLPGVV AGIGGYGNCL GLPNIGGEVV FDPCYQGNPL VNALCVGVLP VDRLQNKAAA 

       250        260        270        280        290        300 
GTGNVVVLMG AKTGRDGIGG VSVLASATFD EGSEQRRPSV QVGDPFIEKL LIEACLELYD 

       310        320        330        340        350        360 
EQLVVGIQDL GGAGLTCALA ETAAAAGTGM RVWLERVPLR EPSMEPHEIL ASESQERMLL 

       370        380        390        400        410        420 
VVEPEKLEAV LQTAEKWGVL ATAIGEVTAP APDGQPGRLV ITWRDHLVVD VPPGSLADDG 

       430        440        450        460        470        480 
PVYHRPMREP ADLILLQADR AETLPRPSDP DSLRETVLRM IASPNLADKT WVTEQYDRYV 

       490        500        510        520        530        540 
LGNTVLAQPE DSGVIRIDER SGIGIALSVD GNGRYARLDP YHGAKLALAE AYRNVAVTGA 

       550        560        570        580        590        600 
KPIAVTDCLN FGSPEDPGVM WQFAEAVRGI ADGCGELGIP VTGGNVSFYN QTGAAAIHPT 

       610        620        630        640        650        660 
PVVGVLGVLD DVADRIPMGF VPRDGGHDQI YLLGDTNVEL SGSEWAWATH EHLGGVPPRV 

       670        680        690        700        710        720 
DLDRERAIAD LMAVAARGGH LSSAHDLSDG GLAQSLVESC LRRGVGARVT LPEQFTGGSM 

       730        740        750        760        770        780 
PFVFLFSESA GRVLVSVPRG HEKAFTALAA EHGVPCELIG VTDTAGGALE LHGQFRLGLD 

       790        800        810        820        830        840 
ELRAAHSATL PRLFGGAELG AANASAVGDA GSPAGAVATP PVTMTEEPTA TGGPAAPIDT 


EPPPGADER

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References

[1]"Complete sequence of Salinispora arenicola CNS-205."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABV96094.1.
RefSeqYP_001535085.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8LXM8.
ModBaseSearch...

Protein-protein interaction databases

STRING391037.Sare_0159.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV96094; ABV96094; Sare_0159.
GeneID5706566.
KEGGsaq:Sare_0159.
PATRIC23428739. VBISalAre38676_0164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000238227.
KOK01952.
OMAWSEHCCY.
ProtClustDBPRK01213.

Enzyme and pathway databases

BioCycSARE391037:GH66-365-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8LXM8_SALAI
AccessionPrimary (citable) accession number: A8LXM8
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info