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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei730 – 7301ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-3488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sare_3451
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
ProteomesiUP000001153 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligasePRO_0000334810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_3451.

Structurei

3D structure databases

ProteinModelPortaliA8LX93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi65 – 7612"HIGH" regionAdd
BLAST
Motifi727 – 7315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LX93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAAASDIP PFRYTAALAD EIERRWQDIW EREGTFHAPN PTGPLADPEH
60 70 80 90 100
PRAGAEKLYV LDMFPYPSGA GLHVGHPLGY IGTDCFARYQ RMAGRNVLHA
110 120 130 140 150
MGFDAFGLPA EQYAVQTGTH PRTTTEANIA RYKAQLRRLG LAHDERRSVA
160 170 180 190 200
TIDADFYRWT QWVFLQIYNA WYDREAKRAR PIAELIAEFS GGVRRTPDGR
210 220 230 240 250
PWRELTDVER RSVVDEYRLA YVSQAPVNWC PGLGTVLANE EVTADGRSER
260 270 280 290 300
GNFPVFKRNL KQWMMRITAY GDRLLDDLDK LDWPEPIKLM QRNWIGRSIG
310 320 330 340 350
AHIEFPTSAG DSSAVGEPRI NVFTTRPDTI FGATYLVLAP EHALVDDLVP
360 370 380 390 400
TAWPSGTRDA WTGGQASPRA AVAGYRKVAA AKTDMERQAE TKEKTGVFIG
410 420 430 440 450
AYATNPVTGA QIPIFIADYV LAGYGTGAIM AVPGQDERDW AFAEVFDLPI
460 470 480 490 500
VRTVRPAEGF DGKAYTGEGP AINSAAPERG LNLDGLGVAE AKARTTAWLE
510 520 530 540 550
ASGHGSGAVT YRLRDWLFSR QRYWGEPFPI VYDETGAAIA LPEDMLPVEL
560 570 580 590 600
PEVDDFSPRT FDPADAGSNP ETPLSRRRDW VEVELDLGDG PKRYTRETNV
610 620 630 640 650
MPQWAGSCWY ELRYLDPTNA DRFVDPDTER YWMGPRGEGD CGGTDLYVGG
660 670 680 690 700
AEHAVLHLLY ARFWHKVLYD LGHVSSFEPF RKLFNQGYIQ AYAYTDARGA
710 720 730 740 750
YVPAEEVVER SGAYYLGDVE VSREYGKMGK SLRNVVTPDE MCAAYGADTF
760 770 780 790 800
RVYEMSMGPL EVSRPWETRA VVGSFRFLQR VWRAIVDERS GASRVVDAPA
810 820 830 840 850
DEATRRLLHR IVDGVRGDME AMRFNTSVAK LIELTNALTR LPATPREVAE
860 870 880 890 900
PLVLMVAPFA PHVAEELWRR MGHPTSLAYA DFPVADPDLL VAESVTYPVQ
910 920 930 940 950
VNGKVRGRVQ VPADASEEVV RAAALDAVAT ALEGREPRKV IVVPGRMVSV

VR
Length:952
Mass (Da):106,026
Last modified:December 4, 2007 - v1
Checksum:i37BD1C3CAC796EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV99253.1.
RefSeqiWP_012183545.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV99253; ABV99253; Sare_3451.
GeneIDi5708200.
KEGGisaq:Sare_3451.
PATRICi23435437. VBISalAre38676_3479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000850 Genomic DNA. Translation: ABV99253.1.
RefSeqiWP_012183545.1. NC_009953.1.

3D structure databases

ProteinModelPortaliA8LX93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391037.Sare_3451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV99253; ABV99253; Sare_3451.
GeneIDi5708200.
KEGGisaq:Sare_3451.
PATRICi23435437. VBISalAre38676_3479.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciSARE391037:GH66-3488-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiSYL_SALAI
AccessioniPrimary (citable) accession number: A8LX93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: July 22, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.