Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8LX93

- SYL_SALAI

UniProt

A8LX93 - SYL_SALAI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei730 – 7301ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSARE391037:GH66-3488-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sare_3451
    OrganismiSalinispora arenicola (strain CNS-205)
    Taxonomic identifieri391037 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
    ProteomesiUP000001153: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 952952Leucine--tRNA ligasePRO_0000334810Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391037.Sare_3451.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LX93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi65 – 7612"HIGH" regionAdd
    BLAST
    Motifi727 – 7315"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8LX93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAAASDIP PFRYTAALAD EIERRWQDIW EREGTFHAPN PTGPLADPEH    50
    PRAGAEKLYV LDMFPYPSGA GLHVGHPLGY IGTDCFARYQ RMAGRNVLHA 100
    MGFDAFGLPA EQYAVQTGTH PRTTTEANIA RYKAQLRRLG LAHDERRSVA 150
    TIDADFYRWT QWVFLQIYNA WYDREAKRAR PIAELIAEFS GGVRRTPDGR 200
    PWRELTDVER RSVVDEYRLA YVSQAPVNWC PGLGTVLANE EVTADGRSER 250
    GNFPVFKRNL KQWMMRITAY GDRLLDDLDK LDWPEPIKLM QRNWIGRSIG 300
    AHIEFPTSAG DSSAVGEPRI NVFTTRPDTI FGATYLVLAP EHALVDDLVP 350
    TAWPSGTRDA WTGGQASPRA AVAGYRKVAA AKTDMERQAE TKEKTGVFIG 400
    AYATNPVTGA QIPIFIADYV LAGYGTGAIM AVPGQDERDW AFAEVFDLPI 450
    VRTVRPAEGF DGKAYTGEGP AINSAAPERG LNLDGLGVAE AKARTTAWLE 500
    ASGHGSGAVT YRLRDWLFSR QRYWGEPFPI VYDETGAAIA LPEDMLPVEL 550
    PEVDDFSPRT FDPADAGSNP ETPLSRRRDW VEVELDLGDG PKRYTRETNV 600
    MPQWAGSCWY ELRYLDPTNA DRFVDPDTER YWMGPRGEGD CGGTDLYVGG 650
    AEHAVLHLLY ARFWHKVLYD LGHVSSFEPF RKLFNQGYIQ AYAYTDARGA 700
    YVPAEEVVER SGAYYLGDVE VSREYGKMGK SLRNVVTPDE MCAAYGADTF 750
    RVYEMSMGPL EVSRPWETRA VVGSFRFLQR VWRAIVDERS GASRVVDAPA 800
    DEATRRLLHR IVDGVRGDME AMRFNTSVAK LIELTNALTR LPATPREVAE 850
    PLVLMVAPFA PHVAEELWRR MGHPTSLAYA DFPVADPDLL VAESVTYPVQ 900
    VNGKVRGRVQ VPADASEEVV RAAALDAVAT ALEGREPRKV IVVPGRMVSV 950
    VR 952
    Length:952
    Mass (Da):106,026
    Last modified:December 4, 2007 - v1
    Checksum:i37BD1C3CAC796EE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99253.1.
    RefSeqiYP_001538244.1. NC_009953.1.

    Genome annotation databases

    EnsemblBacteriaiABV99253; ABV99253; Sare_3451.
    GeneIDi5708200.
    KEGGisaq:Sare_3451.
    PATRICi23435437. VBISalAre38676_3479.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000850 Genomic DNA. Translation: ABV99253.1 .
    RefSeqi YP_001538244.1. NC_009953.1.

    3D structure databases

    ProteinModelPortali A8LX93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391037.Sare_3451.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV99253 ; ABV99253 ; Sare_3451 .
    GeneIDi 5708200.
    KEGGi saq:Sare_3451.
    PATRICi 23435437. VBISalAre38676_3479.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SARE391037:GH66-3488-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNS-205.

    Entry informationi

    Entry nameiSYL_SALAI
    AccessioniPrimary (citable) accession number: A8LX93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3