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A8LX93

- SYL_SALAI

UniProt

A8LX93 - SYL_SALAI

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Protein
Leucine--tRNA ligase
Gene
leuS, Sare_3451
Organism
Salinispora arenicola (strain CNS-205)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei730 – 7301ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSARE391037:GH66-3488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sare_3451
OrganismiSalinispora arenicola (strain CNS-205)
Taxonomic identifieri391037 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeSalinispora
ProteomesiUP000001153: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligaseUniRule annotation
PRO_0000334810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391037.Sare_3451.

Structurei

3D structure databases

ProteinModelPortaliA8LX93.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi65 – 7612"HIGH" regionUniRule annotation
Add
BLAST
Motifi727 – 7315"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LX93-1 [UniParc]FASTAAdd to Basket

« Hide

MTEAAASDIP PFRYTAALAD EIERRWQDIW EREGTFHAPN PTGPLADPEH    50
PRAGAEKLYV LDMFPYPSGA GLHVGHPLGY IGTDCFARYQ RMAGRNVLHA 100
MGFDAFGLPA EQYAVQTGTH PRTTTEANIA RYKAQLRRLG LAHDERRSVA 150
TIDADFYRWT QWVFLQIYNA WYDREAKRAR PIAELIAEFS GGVRRTPDGR 200
PWRELTDVER RSVVDEYRLA YVSQAPVNWC PGLGTVLANE EVTADGRSER 250
GNFPVFKRNL KQWMMRITAY GDRLLDDLDK LDWPEPIKLM QRNWIGRSIG 300
AHIEFPTSAG DSSAVGEPRI NVFTTRPDTI FGATYLVLAP EHALVDDLVP 350
TAWPSGTRDA WTGGQASPRA AVAGYRKVAA AKTDMERQAE TKEKTGVFIG 400
AYATNPVTGA QIPIFIADYV LAGYGTGAIM AVPGQDERDW AFAEVFDLPI 450
VRTVRPAEGF DGKAYTGEGP AINSAAPERG LNLDGLGVAE AKARTTAWLE 500
ASGHGSGAVT YRLRDWLFSR QRYWGEPFPI VYDETGAAIA LPEDMLPVEL 550
PEVDDFSPRT FDPADAGSNP ETPLSRRRDW VEVELDLGDG PKRYTRETNV 600
MPQWAGSCWY ELRYLDPTNA DRFVDPDTER YWMGPRGEGD CGGTDLYVGG 650
AEHAVLHLLY ARFWHKVLYD LGHVSSFEPF RKLFNQGYIQ AYAYTDARGA 700
YVPAEEVVER SGAYYLGDVE VSREYGKMGK SLRNVVTPDE MCAAYGADTF 750
RVYEMSMGPL EVSRPWETRA VVGSFRFLQR VWRAIVDERS GASRVVDAPA 800
DEATRRLLHR IVDGVRGDME AMRFNTSVAK LIELTNALTR LPATPREVAE 850
PLVLMVAPFA PHVAEELWRR MGHPTSLAYA DFPVADPDLL VAESVTYPVQ 900
VNGKVRGRVQ VPADASEEVV RAAALDAVAT ALEGREPRKV IVVPGRMVSV 950
VR 952
Length:952
Mass (Da):106,026
Last modified:December 4, 2007 - v1
Checksum:i37BD1C3CAC796EE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99253.1.
RefSeqiYP_001538244.1. NC_009953.1.

Genome annotation databases

EnsemblBacteriaiABV99253; ABV99253; Sare_3451.
GeneIDi5708200.
KEGGisaq:Sare_3451.
PATRICi23435437. VBISalAre38676_3479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000850 Genomic DNA. Translation: ABV99253.1 .
RefSeqi YP_001538244.1. NC_009953.1.

3D structure databases

ProteinModelPortali A8LX93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391037.Sare_3451.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV99253 ; ABV99253 ; Sare_3451 .
GeneIDi 5708200.
KEGGi saq:Sare_3451.
PATRICi 23435437. VBISalAre38676_3479.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SARE391037:GH66-3488-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNS-205.

Entry informationi

Entry nameiSYL_SALAI
AccessioniPrimary (citable) accession number: A8LX93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi