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A8LVF4 (KMO_SALAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9
Alternative name(s):
Kynurenine 3-hydroxylase
Gene names
Name:kmo
Ordered Locus Names:Sare_4893
OrganismSalinispora arenicola (strain CNS-205) [Complete proteome] [HAMAP]
Taxonomic identifier391037 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Salinispora

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.

Catalytic activity

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.

Cofactor

FAD By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandFAD
Flavoprotein
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionkynurenine 3-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Kynurenine 3-monooxygenase
PRO_0000361943

Sequences

Sequence LengthMass (Da)Tools
A8LVF4 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 99AE6CB347EFF8C5

FASTA45449,556
        10         20         30         40         50         60 
MNRRRERVVV VGAGLAGSLA ALYLARQGHE VDIFERRPDP RSALAGPEGR SINLGLSARG 

        70         80         90        100        110        120 
MRALDGVGLL ADVLKHSVPM RDRVVHSPDG GVRAQPYGVR EHEILHSVLR EELISLVVSA 

       130        140        150        160        170        180 
AEAEPGVRFH FDSLLTSLDR ETGTVRVAPT AGGEASTVTA DLVVGADGVF STVRQQMQHG 

       190        200        210        220        230        240 
LRANYAQDFL PWGYKELTIP VGTDGQPRVR LEALHVWPGH EALMVAHPNR DGSLTCTLFM 

       250        260        270        280        290        300 
AHEGPVSFAA LDTPAAVRDF FRRRFPDAEE LMPDLVREIT EHPVGHLVTV RTAPWRYADR 

       310        320        330        340        350        360 
VVLIGDAAHA VYPFYGQGMN SAFEDCVVLD ECLTAHPDRA AALAAYEAAR KPHTDVLADL 

       370        380        390        400        410        420 
STANFEDLRD RVHRLGYSAS AAADRLLARL LPQRWVPLYA MVAHTTIPYA DALARANRQD 

       430        440        450 
RILRRAGAGL TLAVGLAATA AALRVGRRRR AARR

« Hide

References

[1]"Complete sequence of Salinispora arenicola CNS-205."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K. expand/collapse author list , Jenkins C., Udwary D., Xiang L., Gontang E., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNS-205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000850 Genomic DNA. Translation: ABW00643.1.
RefSeqYP_001539633.1. NC_009953.1.

3D structure databases

ProteinModelPortalA8LVF4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LVF4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5707545.
GenomeReviewsGene locus Sare_4893 in contig CP000850_GR.
KEGGsaq:Sare_4893.
PATRIC23438400. VBISalAre38676_4940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG430104.
OMAWGYKELT.
ProtClustDBCLSK903475.

Enzyme and pathway databases

BioCycSARE391037:SARE_4893-MONOMER.

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
KOK00486.
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Entry information

Entry nameKMO_SALAI
AccessionPrimary (citable) accession number: A8LVF4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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