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Protein

Catalase-peroxidase

Gene

katG

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95Transition state stabilizerUniRule annotation1
Active sitei99Proton acceptorUniRule annotation1
Metal bindingi267Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Dshi_3801
Encoded oniPlasmid pDSHI020 Publication
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Plasmid pDSHI02

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547691 – 725Catalase-peroxidaseAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki98 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8LTG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LTG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDLRNVT GCPVMHGGNT GMNTSPVRWW PNALNLDILH QHGARVSPMD
60 70 80 90 100
PDYDHREAVK ALDFQGVWDD VDKLLTDSQD WWPADWGHYG GLFIRLSWHA
110 120 130 140 150
AGSYRLGDGR GGAGTGNLRF EPLNSWPDNA SLEKARRLLW PVKKKYGNAL
160 170 180 190 200
SWADLLVLAG TVAYSNMGLK TFGFAFGRKD IWGPEIDINW GSDSEILAPT
210 220 230 240 250
DERVTDVADA NSMANPLAAS HMGLIYVNPE GVNGTPDPAQ TAKYVRMTFA
260 270 280 290 300
RMAMNDEETA ALTVGGHTVG KAHGGTMADK VGADPAGCPV HMQGFGWENP
310 320 330 340 350
GFDGNANTAH TSGLEGAWTS NPTQWDNGYL ELLFKYDWEV TKSRAGAFQW
360 370 380 390 400
EPVNIAEEDM VPDATDPSIK HNPIMTDADM AMKVDPIYRE ICERFHKDPD
410 420 430 440 450
YLADTFARAW FKLTHRDMGP KANYYGPFVP QEDLIWQDPI PEGPTGYDVD
460 470 480 490 500
ALKAKIAESG LSAAEMIATA WDSARTFRGS DMRGGANGAR IRLVPQKDWA
510 520 530 540 550
GNEPERLAKV LGILEPLAAA AGASIADTIV LAGNVGIEMA IKAAGQDVPV
560 570 580 590 600
PFAPGRGDAT DAMTDAESFE VMEPFADGFR NWSKERYSVS PEELMLDRAQ
610 620 630 640 650
LLGLTAAEMA VLVGGLRVLG ANHGGSAHGV FTDRVGTLTT DFFQTITDMA
660 670 680 690 700
YKWVPLDDGT YEIRDRKSGD TVYTATSADL VFGSNSQLRA IAEVYAQDDN
710 720
ETKFVRDFVA AWTKVMNADR FDLLA
Length:725
Mass (Da):79,174
Last modified:December 4, 2007 - v1
Checksum:iEF855E21EAE8FEA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000832 Genomic DNA. Translation: ABV95531.1.
RefSeqiWP_012187194.1. NC_009956.1.

Genome annotation databases

EnsemblBacteriaiABV95531; ABV95531; Dshi_3801.
KEGGidsh:Dshi_3801.
PATRICi21820415. VBIDinShi9476_3934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000832 Genomic DNA. Translation: ABV95531.1.
RefSeqiWP_012187194.1. NC_009956.1.

3D structure databases

ProteinModelPortaliA8LTG4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV95531; ABV95531; Dshi_3801.
KEGGidsh:Dshi_3801.
PATRICi21820415. VBIDinShi9476_3934.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_DINSH
AccessioniPrimary (citable) accession number: A8LTG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.